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Sponsors and Collaborators: |
Wageningen University Wageningen Centre for Food Sciences ZonMw: The Netherlands Organisation for Health Research and Development |
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Information provided by: | Wageningen University |
ClinicalTrials.gov Identifier: | NCT00110604 |
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
Condition | Intervention |
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Atherosclerosis Vascular Disease Cognitive Decline Hearing Loss Inflammation Age-Related Memory Disorder |
Behavioral: folic acid (0.8 mg) |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial |
Estimated Enrollment: | 835 |
Study Start Date: | September 2000 |
Estimated Study Completion Date: | December 2004 |
Low levels of B vitamins, in particular folate, and high levels of plasma total homocysteine, have been associated with a variety of age-related diseases and disorders, including cardiovascular disease, dementia and hearing impairment. Extra folate, for example in the form of folic acid, is known to decrease the concentrations of plasma total homocysteine.
We examined whether 0.8 mg/d folic acid could slow down atherosclerotic progression and the above mentioned age-related processes.
Ages Eligible for Study: | 50 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Netherlands, Gelderland | |
Wageningen University | |
Wageningen, Gelderland, Netherlands, 6700 EV |
Principal Investigator: | Petra Verhoef, PhD | Wageningen Centre for Food Sciences |
Study ID Numbers: | Pou.0224L, ZonMw 20010002 |
Study First Received: | May 10, 2005 |
Last Updated: | December 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00110604 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Folic acid Atherosclerosis Cognitive function Hearing |
Inflammation Hemostasis Arterial stiffness |
Atherosclerosis Arterial Occlusive Diseases Sensation Disorders Otorhinolaryngologic Diseases Vascular Diseases Arteriosclerosis Memory Disorders Ear Diseases |
Inflammation Folic Acid Signs and Symptoms Deafness Hearing Disorders Neurologic Manifestations Hearing Loss Neurobehavioral Manifestations |
Vitamin B Complex Pathologic Processes Hematinics Therapeutic Uses Growth Substances Vitamins |
Hematologic Agents Physiological Effects of Drugs Nervous System Diseases Cardiovascular Diseases Micronutrients Pharmacologic Actions |