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Sponsored by: |
Children's Healthcare of Atlanta |
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Information provided by: | Children's Healthcare of Atlanta |
ClinicalTrials.gov Identifier: | NCT00207909 |
Acute kidney failure is common in children in the Pediatric Intensive Care Unit (PICU). You are being asked to participate in this study because your child is being treated for kidney failure with continuous veno-venous hemofiltration (CVVH). CVVH is a continuous, gentle form of removing excess fluids and small wastes from the blood, similar to kidney dialysis (artificial kidney). It is an accepted therapy for temporary support of kidney failure. In some patients with acute kidney failure, beginning CVVH is followed by a temporary decrease of urine output. The reason why this happens is currently unknown. The purpose of this study is to determine why this happens.
Condition |
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Renal Failure |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | The Role of Hemodynamics, Cytokine Response, and Modulators of Apoptosis on Urine Output in Patients With Acute Renal Failure on CVVH |
Estimated Enrollment: | 40 |
Study Start Date: | February 2005 |
Acute renal failure is common in children in the pediatric intensive care unit. Renal replacement therapies such as peritoneal dialysis (PD), intermittent hemodialysis (IHD), and continuous venovenous hemofiltration (CVVH) have been used in the management of acute renal failure. CVVH is becoming increasingly utilized in pediatric acute renal failure. However, in patients who have acute renal failure, the institution of CVVH is often followed by a progression to oliguria or anuria. The underlying pathophysiology of this change is unknown. We believe that this progression is influenced by changes in the renin-angiotensin axis, cytokine response, and other modifiers of renal hemodynamics. By serially measuring components of those systems, this study will attempt to elucidate the pathophysiology of the decreased urine output seen with institution of CVVH. Once this process is understood, future studies should focus on prevention and treatment of this complication.
General Hypothesis
The decrease in urine output seen after the initiation of CVVH is associated with increased angiotensin converting enzyme (ACE) levels, increased renin activity, increased angiotensin II levels, increased atrial naturetic peptide (ANP) levels, increased endothelin-1 levels, increased arginine vasopressin (AVP) levels, and alterations of cytokine levels and modulators of apoptosis.
Ages Eligible for Study: | 5 Months and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
The general goal of patient selection is to enroll all children for whom CVVH is instituted.
Inclusion criteria:
Age
Indication for CVVH: including, but not limited to :
Exclusion Criteria:
Age
Non-adherence:
Inability or unwillingness of the legal guardian to provide consent or inability or unwillingness of the child to provide assent
Contact: Matthew Paden, MD | 404-785-1750 | matthew.paden@choa.org |
Contact: Kristine M Rogers, RN | 404-785-1215 | kristine.rogers@choa.org |
United States, Georgia | |
Children's Healthcare of Atlanta at Egleston | Recruiting |
Atlanta, Georgia, United States, 30322 | |
Contact: Matt Paden, MD 404-785-1750 matthew.paden@choa.org | |
Contact: Krstine M Rogers, RN 404-785-1215 kristine.rogers@choa.org | |
Principal Investigator: James D Fortenberry, MD | |
Principal Investigator: Matt Paden, MD |
Principal Investigator: | James D Fortenberry, MD | Children's Healthcare of Atlanta |
Study ID Numbers: | 04-114, 06585 |
Study First Received: | September 13, 2005 |
Last Updated: | June 13, 2007 |
ClinicalTrials.gov Identifier: | NCT00207909 |
Health Authority: | United States: Food and Drug Administration |
Acute Renal Failure Contiuous Veno Venous Hemofiltration |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Acute |
Kidney Diseases Kidney Failure, Acute Kidney Failure |