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Sponsors and Collaborators: |
Bispebjerg Hospital University of Copenhagen Glostrup University Hospital,Copenhagen The Danish Medical Research Council The Lundbeck Foundation |
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Information provided by: | Bispebjerg Hospital |
ClinicalTrials.gov Identifier: | NCT00206999 |
We wanted to compare the relation of two different psychophysiological paradigms (PrePulse Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we wanted to test the effect of the combined serotonin- and noradrenaline re-uptake inhibitor, imipramine, on these measures. The primary hypothesis was that PPI and P50 gating would not correlate with each other at baseline. The secondary hypothesis was that increased noradrenergic and serotonergic activity would disrupt PPI as well as P50 gating.
Condition | Intervention |
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Healthy Volunters |
Drug: imipramine |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacodynamics Study |
Official Title: | Early Information Processing in Healthy Controls: Studies on the Relation Between Two Different Paradigms (PPI and P50ERP) and Effects of Pharmacological Interventions |
Ages Eligible for Study: | 18 Years to 35 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Denmark | |
Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Center Glostrup | |
Glostrup, Denmark, DK-2600 |
Study Director: | Birte Glenthoj, MD, DMSc. | Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychaitric Center Glostrup, Ndr. Ringvej, DK-2600 Glostrup, Denmark |
Study ID Numbers: | 363052-2, KF 01-305/99, KF 11-061/03, KF 11-068/03, KF 11-096/04 |
Study First Received: | September 11, 2005 |
Last Updated: | September 11, 2006 |
ClinicalTrials.gov Identifier: | NCT00206999 |
Health Authority: | Denmark: National Board of Health |
Psychophysiology PPI P50 suppression Imipramine |
Imipramine Healthy |
Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Adrenergic Uptake Inhibitors Therapeutic Uses |
Physiological Effects of Drugs Psychotropic Drugs Central Nervous System Agents Pharmacologic Actions Antidepressive Agents Antidepressive Agents, Tricyclic |