Inclusion Criteria:

• African American
• 18-75 years of age
• Smoke more than 10 cigarettes per day
• Have a functioning telephone number
• Be interested in quitting smoking
• Be willing to take 3 months of Chantix
• Be willing to complete all study visits

Exclusion Criteria:

• Renal impairment
• Evidence or history of clinically significant allergic reactions to Chantix
• Cardiovascular event in the past month
• History of alcohol or drug abuse/dependency in the past year
• Major depressive disorder in the last year requiring treatment
• History of panic disorder
• Psychosis, bipolar or eating disorder
• Use of antidepressants, antipsychotics, mood stabilizers/anticonvulsants or naltrexone
• Use of tobacco products other than cigarettes
• Use of nicotine replacement therapy, buproprion, clonidine or nortriptyline in the month prior to enrollment
• Prior use of Chantix
• Women who are pregnant, contemplating getting pregnant or breastfeeding
• Plans to move from Kansas City during the 3 month treatment phase
• Another household member enrolled in the study