Does Pulmonary Rehabilitation Change Self-Selected And Maximum Sustainable Walking Speed In Patients With Lung Disease? - Full Text View

Sponsored by:	West Park Healthcare Centre
Information provided by:	West Park Healthcare Centre
ClinicalTrials.gov Identifier:	NCT00781183

Purpose

Exercise training has been shown to reduce breathlessness and improve the exercise tolerance of people with lung disease. However, the effect of exercise training on the walking speed selected by these people during day-to-day life is unknown. Furthermore, we do not know if exercise training changes the maximum speed that these people can walk at for a long period of time. This study will examine the relationship between walking speed and walking endurance before and following exercise training in people with lung disease and contribute importantly to our understanding of how patients choose to walk in relation to their capabilities.

Condition	Intervention
COPD Chronic Lung Disease	Other: pulmonary rehabilitation

MedlinePlus related topics: Exercise and Physical Fitness Methamphetamine Rehabilitation

Drug Information available for: Amphetamine Methamphetamine

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Open Label, Single Group Assignment
Official Title:	Does Pulmonary Rehabilitation Change The Self-Selected And Maximum Sustainable Walking Speed In Patients With Symptomatic Lung Disease?

Further study details as provided by West Park Healthcare Centre:

Primary Outcome Measures:

Endurance walk time (EWT) defined as the time a patient can walk at a self-selected speed until they first need to stop and rest [ Time Frame: Pre and post pulmonary rehabilitation ] [ Designated as safety issue: No ]
The maximum sustainable walk speed (MSWS) defined as the maximum speed that a patient walk for at for > 24 minutes [ Time Frame: Pre and post pulmonary rehabilitation ] [ Designated as safety issue: No ]

Estimated Enrollment:	100
Study Start Date:	December 2008
Estimated Study Completion Date:	December 2010
Estimated Primary Completion Date:	December 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
pulmonary rehabilitation: Experimental patients that are enrolled in pulmonary rehabilitation	Other: pulmonary rehabilitation 6-weeks of in-patient pulmonary rehabilitation or 12-weeks of out-patient pulmonary rehabilitation

Detailed Description:

Rationale: Pulmonary rehabilitation (PR) is considered a standard of care for patients with symptomatic lung disease. It has achieved strong evidence for reducing symptoms and improving exercise tolerance. Walking is the most common form of physical activity and most individuals need to walk in the course of their daily activities. Chosen walking speed is a good indicator of the debilitating effects of disease and improvement in usual walk speed has been associated with a substantial reduction in mortality in elderly subjects. Therefore, it is important for clinicians to understand how patients choose to walk in relation to their capabilities as well as to know how this relationship changes with PR.

The main purpose of this study is to examine the relationship between walking speed and walking endurance before and after PR.

Primary aim: to estimate the maximum walking speed that can be sustained for > 24 min (i.e. maximum sustainable walking speed; MSWS) from the relationship between walking speed and walking time in patients with symptomatic lung disease.

Secondary aims: (i) to determine if chosen speed during the endurance walk test is different from the MSWS, (ii) to determine if MSWS and speed chosen for the endurance walk test changes in response to PR and, (iii) to measure the repeatability of endurance walk time (EWT), defined as the duration a patient can walk at a self-selected pace before that first need to stop and rest.

Significance: Walking is the most common form of physical activity. Chosen walking speed and the capacity to endure walking at different speeds can help quantify disability. Also, studies that examine the effect of PR on survival are not available. However, indirect evidence suggests that PR improves many of the risk factors associated with mortality in patients with COPD. This study will examine the effect of PR on the usual walking speed selected by individuals with symptomatic lung disease, which has been demonstrated to be a predictor of mortality in elderly individuals. Therefore, our study may contribute to the indirect evidence for the effects of PR on survival.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients referred to pulmonary rehabilitation with symptomatic chronic lung disease

Exclusion Criteria:

Co-morbid conditions that adversely affect exercise capacity or participation in a pulmonary rehabilitation program; inability to provide written informed consent; weaning doses of oral corticosteroids or methylxanthines

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00781183

Contacts

Contact: Roger S Goldstein, MD

1 416 243 3600 ext 3631

rgoldstein@westpark.org

Locations

Canada, Ontario
West Park Healthcare Centre
Toronto, Ontario, Canada, M6M 2J5

Sponsors and Collaborators

West Park Healthcare Centre

Investigators

Principal Investigator:

Roger S Goldstein, MD

West Park Healthcare Centre

More Information

Responsible Party:	West Park Healthcare Centre ( Dr. Roger Goldstein )
Study ID Numbers:	D6255L00002
Study First Received:	October 27, 2008
Last Updated:	October 27, 2008
ClinicalTrials.gov Identifier:	NCT00781183
Health Authority:	Canada: Ethics Review Committee

Keywords provided by West Park Healthcare Centre:

COPD
rehabilitation
walking

Study placed in the following topic categories:

Methamphetamine
Respiratory Tract Diseases
Lung Diseases
Amphetamine

ClinicalTrials.gov processed this record on January 16, 2009