Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease - Full Text View

Sponsored by:	Yokohama City University Medical Center
Information provided by:	Yokohama City University Medical Center
ClinicalTrials.gov Identifier:	NCT00298129

Purpose

Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.

Condition	Intervention
Diabetes Mellitus Essential Hypertension Renal Failure Chronic Nephropathy	Device: Ambulatory blood pressure monitoring

MedlinePlus related topics: Diabetes High Blood Pressure Kidney Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Convenience Sample, Prospective Study
Official Title:	Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease

Further study details as provided by Yokohama City University Medical Center:

Enrollment:	278
Study Start Date:	February 2004
Study Completion Date:	December 2006

Detailed Description:

The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance. Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.

Eligibility

Ages Eligible for Study:	20 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Hypertensive patients with diabetes mellitus
Hypertensive patients
Hypertensive patients with renal disease
Patients with chronic renal disease

Exclusion Criteria:

Cardiac, hematologic or hepatic disease
Cerebral infarction or hemorrhage
Other major diseases.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00298129

Locations

Japan
Yokohama City University Center Hospital
Yokohama, Japan, 232-0024

Sponsors and Collaborators

Yokohama City University Medical Center

Investigators

Principal Investigator:	Gen Yasuda, MD	Yokohama City University Center Hospital
Principal Investigator:	Gen Yasuda, MD	Yokohama City University Center Hospital
Principal Investigator:	Gen Yasuda, MD	Yokohama City University Center Hospital

More Information

Publications:

Yasuda G, Nagasawa T, Umemura S, Shionoiri H, Ishii M. The impaired control of plasma renin activity in hypertensive patients with end-stage renal disease due to chronic glomerulonephritis. Clin Nephrol. 1994 Nov;42(5):300-8.

Study ID Numbers:	7332-3
Study First Received:	February 28, 2006
Last Updated:	May 8, 2007
ClinicalTrials.gov Identifier:	NCT00298129
Health Authority:	Japan: Ministry of Health, Labor and Welfare

Study placed in the following topic categories:

Renal Insufficiency
Metabolic Diseases
Kidney Failure, Chronic
Diabetes Mellitus
Vascular Diseases
Endocrine System Diseases
Urologic Diseases
Renal Insufficiency, Chronic

Essential hypertension
Endocrinopathy
Kidney Diseases
Metabolic disorder
Glucose Metabolism Disorders
Kidney Failure
Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009