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Sponsored by: |
Emory University |
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Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00211081 |
Ultrasound is a technique that can provide images of the blood vessels such as arteries. The size of the arteries, such as the main blood vessel in the arm, can change under different conditions. Using ultrasound we can see how arteries change with movement or even drugs. We want to use ultrasound to see how blood vessels look in patients with Congestive Heart Failure (CHF) and to also see how a drug called Spironolactone, commonly prescribed for patients with this disease, effects blood vessel function in patients with congestive heart failure. This information may be used to change the standard of care for patients with heart failure especially if we show that Spironolactone has a positive effect on vessel function in patients with CHF.
Condition | Intervention |
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Congenital Disorders |
Drug: Spironolactone (drug) |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Historical Control, Single Group Assignment, Efficacy Study |
Official Title: | Impact of Spironolactone on Endothelial Function in Patients With Single Ventricle Heart |
Enrollment: | 10 |
Study Start Date: | November 2004 |
Study Completion Date: | June 2008 |
Primary Completion Date: | June 2008 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Georgia | |
Emory Clinic | |
Atlanta, Georgia, United States, 30322 |
Principal Investigator: | William T Mahle, MD | Emory University |
Principal Investigator: | Arshed Quyyumi, MD | Emory University |
Principal Investigator: | Wendy M Book, MD | Emory University |
Principal Investigator: | Michael E McConnell, MD | Emory University |
Responsible Party: | Emory University Institutional Review Board ( Chairman ) |
Study ID Numbers: | 954-2004 |
Study First Received: | September 13, 2005 |
Last Updated: | July 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00211081 |
Health Authority: | United States: Food and Drug Administration |
Congenital Heart Disease Spironolactone >17 years old undergone Fontan procedure endothelial function |
Heart Diseases Single ventricular heart Spironolactone |
Aldosterone Antagonists Natriuretic Agents Therapeutic Uses Hormone Antagonists Physiological Effects of Drugs |
Diuretics Hormones, Hormone Substitutes, and Hormone Antagonists Cardiovascular Agents Pharmacologic Actions |