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Sponsors and Collaborators: |
UMC Utrecht Center for Human Drug Research Leiden University Medical Center TI Pharma |
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Information provided by: | UMC Utrecht |
ClinicalTrials.gov Identifier: | NCT00628706 |
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
Condition | Intervention | Phase |
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Reward Tetrahydrocannabinol Endocannabinoids Memory Magnetic Resonance Imaging |
Drug: Delta9-tetrahydrocannabinol (THC) |
Phase I |
Study Type: | Interventional |
Study Design: | Basic Science, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Crossover Assignment, Pharmacokinetics/Dynamics Study |
Official Title: | Investigating the Acute Effects of THC on Functional Brain Systems |
Estimated Enrollment: | 12 |
Study Start Date: | April 2008 |
Estimated Study Completion Date: | July 2008 |
Estimated Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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A: Experimental
Inhalation of THC, using a Volcano vaporizer
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Drug: Delta9-tetrahydrocannabinol (THC)
inhalation of 6 mg liquid THC, vaporized by means of a Volcano vaporizer
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B: Placebo Comparator
Inhalation of vehicle, using a Volcano vaporizer
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Drug: Delta9-tetrahydrocannabinol (THC)
inhalation of 6 mg liquid THC, vaporized by means of a Volcano vaporizer
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Cannabis is by far the most frequently used illicit drug worldwide and has significant effects on memory. Further, cannabis has an addictive potential. These effects are mediated by an action of THC, the main psychoactive ingredient of cannabis, on cannabinoid CB1 receptors. These receptors are particularly highly expressed in brain regions involved in memory and reward. Therefore, in this study we will investigate the acute effects of THC on functional brain systems underlying memory and reward. We will visualize these effects using the latest non-invasive imaging technique: pharmacological MRI (phMRI).
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Matthijs Bossong, MSc | +31-887557950 | m.bossong@umcutrecht.nl |
Netherlands | |
University Medical Center Utrecht | |
Utrecht, Netherlands, 3584CX |
Principal Investigator: | Nick Ramsey, Professor | University Medical Center Utrecht |
Responsible Party: | UMC Utrecht ( Prof. N.F. Ramsey ) |
Study ID Numbers: | THC-phMRI-01 |
Study First Received: | February 24, 2008 |
Last Updated: | February 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00628706 |
Health Authority: | Netherlands: Dutch Health Care Inspectorate; Netherlands: Medical Ethics Review Committee (METC); Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
tetrahydrocannabinol memory reward magnetic resonance imaging endocannabinoids |
Tetrahydrocannabinol |
Sensory System Agents Analgesics, Non-Narcotic Therapeutic Uses Physiological Effects of Drugs Psychotropic Drugs |
Hallucinogens Peripheral Nervous System Agents Analgesics Central Nervous System Agents Pharmacologic Actions |