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Sponsors and Collaborators: |
St. Paul Heart Clinic GlaxoSmithKline |
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Information provided by: | St. Paul Heart Clinic |
ClinicalTrials.gov Identifier: | NCT00123604 |
The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.
Condition | Intervention | Phase |
---|---|---|
Hypertension Type 2 Diabetes Mellitus |
Drug: carvedilol Drug: metoprolol |
Phase IV |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Effects of Carvedilol and Metoprolol on Endothelial Function in Hypertensive Patients With Type 2 Diabetes Mellitus |
Estimated Enrollment: | 36 |
Study Start Date: | June 2004 |
Estimated Study Completion Date: | February 2006 |
Carvedilol and metoprolol are two commonly used blood pressure medications that have both been shown to be effective in controlling hypertension. Although in the same drug class, preliminary data have shown that these medications may have different vascular effects. This study will assess which medication is better at improving artery health independent of their blood pressure lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.
Ages Eligible for Study: | 30 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Minnesota | |
St. Paul Heart Clinic | |
St. Paul, Minnesota, United States, 55102 |
Principal Investigator: | Alan J Bank, M.D. | St. Paul Heart Clinic |
Study ID Numbers: | GSK101598 |
Study First Received: | July 21, 2005 |
Last Updated: | April 10, 2007 |
ClinicalTrials.gov Identifier: | NCT00123604 |
Health Authority: | United States: Institutional Review Board |
beta-blockers endothelial function |
Metabolic Diseases Metoprolol succinate Diabetes Mellitus, Type 2 Vascular Diseases Diabetes Mellitus Endocrine System Diseases |
Endocrinopathy Metoprolol Metabolic disorder Glucose Metabolism Disorders Carvedilol Hypertension |
Vasodilator Agents Neurotransmitter Agents Sympatholytics Adrenergic Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Adrenergic alpha-Antagonists Cardiovascular Agents Antihypertensive Agents |
Pharmacologic Actions Autonomic Agents Therapeutic Uses Adrenergic beta-Antagonists Cardiovascular Diseases Adrenergic Antagonists Peripheral Nervous System Agents Anti-Arrhythmia Agents |