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Sponsored by: |
Children's Hospital Boston |
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Information provided by: | Children's Hospital Boston |
ClinicalTrials.gov Identifier: | NCT00389142 |
Interstitial cystitis (also called painful bladder syndrome, or chronic pelvic pain syndrome) is a common condition with no known cure. It is estimated that every 15 seconds, a person in the USA is diagnosed with interstitial cystitis. Studies have suggested that the condition may be genetic and passed down (or inherited) from one generation to the next.
In this study we are comparing different families' samples and medical information to determine which genetic factors may play a role in interstitial cystitis. We are enrolling families and individuals with IC/PBS/CPPS and their family members (both symptomatic and asymptomatic family members)
Condition |
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Interstitial Cystitis Painful Bladder Syndrome Hypersensitive Bladder Syndrome Chronic Pelvic Pain Syndrome |
Study Type: | Observational |
Study Design: | Family-Based, Prospective |
Official Title: | Genetic Studies in Interstitial Cystitis/Painful Bladder Syndrome/Chronic Pelvic Pain Syndrome |
We will collect and store DNA (via saliva) and urine on all participants.
Estimated Enrollment: | 500 |
Study Start Date: | January 2006 |
Estimated Study Completion Date: | January 2011 |
To fully describe the phenotype of interstitial cystitis (IC)/painful bladder syndrome (PBS)/chronic pelvic pain syndrome (CPPS), in adults and children, and to correlate the phenotypic information to the genotypic findings utilizing linkage analysis and candidate gene studies. A US cohort and a Bulgarian cohort will be recruited. Both individuals and families with IC/PBS/CPPS symptoms will be recruited to give a DNA and urine sample.
Ages Eligible for Study: | 8 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
We are collecting patients throughout North America (including the United States and Canada)
Inclusion Criteria:
Exclusion Criteria:
Contact: Elicia A Estrella, MS, CGC | 617-919-4552 | elicia.estrella@childrens.harvard.edu |
Contact: Stephanie J Brewster, MS, CGC | 617-919-4551 | stephanie.brewster@childrens.harvard.edu |
United States, Massachusetts | |
Children's Hospital | Recruiting |
Boston, Massachusetts, United States, 02115 | |
Contact: Elicia A Estrella, MS, CGC 617-919-4552 elicia.estrella@childrens.harvard.edu | |
Contact: Stephanie J Brewster, MS, CGC 617-919-4551 stephanie.brewster@childrens.harvard.edu | |
Principal Investigator: Jordan Dimitrakov, MD, PhD |
Principal Investigator: | Jordan Dimitrakov, MD, PhD | Children's Hosptial, Boston |
Responsible Party: | Children's Hospital, Boston ( Jordan Dimitrakov, M.D., Ph.D. ) |
Study ID Numbers: | 04-11-160, PHS 398/2590 |
Study First Received: | October 17, 2006 |
Last Updated: | May 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00389142 |
Health Authority: | United States: Institutional Review Board |
pelvic pain urinary frequency painful bladder |
Signs and Symptoms Cystitis, Interstitial Cystocele Pelvic Pain Urologic Diseases |
Urinary Bladder Diseases Neurologic Manifestations Cystitis Pain |
Pathologic Processes Disease Syndrome Nervous System Diseases |