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Sponsored by: |
Tel-Aviv Sourasky Medical Center |
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Information provided by: | Tel-Aviv Sourasky Medical Center |
ClinicalTrials.gov Identifier: | NCT00484978 |
Brain metastases (BM) are the most common intracranial tumors in adults and source of the most common neurological complications of systemic cancer. Surgery and radiation therapy are the most important components in the management of BM with the goal to prolong survival and improve the quality of life. Whole brain radiotherapy (WBRT) has shown to increase local and distant control both with and without surgical resection. However, patients who develop a new or recurrent BM after WBRT and undergo resection are left without adjuvant therapy options. Local recurrence particular in patients with single metastasis does effect both survival and quality of life. In individual cases the option of additional radiotherapy has been suggested and applied. We seek to evaluate the addition of a stereotactic radiosurgery (SRS) boost to the resection cavity both as adjuvant and salvage procedure among patients, who undergo resection of a BM and previously received WBRT or decline WBRT. Goal is to show superior local brain control.
Condition | Intervention | Phase |
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Brain Neoplasms |
Procedure: Stereotactic Radiosurgery |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study |
Official Title: | A Single Center Prospective Phase II Study: Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis |
Estimated Enrollment: | 35 |
Study Start Date: | February 2007 |
Estimated Study Completion Date: | June 2007 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Patient must be in adequate general health, as indicated by:
Exclusion Criteria:
Contact: Andrew A. Kanner, MD | 972-3-6974273 | andrewk@tasmc.health.gov.il |
Contact: Lina Vizelman | 972-3-6974098 | linav@tasmc.health.gov.il |
Israel | |
Tel Aviv Sourasky Medical Center | Recruiting |
Tel Aviv, Israel | |
Contact: Andrew A Kanner, MD 972-3-6974273 andrewk@tasmc.health.gov.il | |
Contact: Lina Vizelman 972-3-6974098 linav@tasmc.health.gov.il |
Principal Investigator: | Andrew A Kanner, MD | Tel Aviv Medical Center, affiliated Tel Aviv University |
Study ID Numbers: | 07-056 TASMC |
Study First Received: | June 11, 2007 |
Last Updated: | June 11, 2007 |
ClinicalTrials.gov Identifier: | NCT00484978 |
Health Authority: | Israel: Ministry of Health |
Stereotactic Radiosurgery Surgery Metastatic tumor to brain radiation Brain Metastases of all pathologies |
Brain Neoplasms Neoplasm Metastasis Central Nervous System Diseases |
Central Nervous System Neoplasms Brain Diseases Nervous System Neoplasms |
Neoplastic Processes Neoplasms Pathologic Processes Neoplasms by Site Nervous System Diseases |