Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

This study has been completed.

Sponsored by:	Mashhad University of Medical Sciences
Information provided by:	Mashhad University of Medical Sciences
ClinicalTrials.gov Identifier:	NCT00484250

Purpose

Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Condition	Intervention	Phase
Oral Lichen Planus	Drug: metronidazole,doxycycline	Phase II

Drug Information available for: Doxycycline Doxycycline calcium Doxycycline hyclate Metronidazole Metronidazole hydrochloride Metronidazole phosphate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study

Further study details as provided by Mashhad University of Medical Sciences:

Enrollment:	20
Study Start Date:	September 2005
Study Completion Date:	May 2006

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00484250

Locations

Iran, Islamic Republic of, Khorasan
Mashhad University Of Medical Sciences(Dentistry School)
Mashhad, Khorasan, Iran, Islamic Republic of, 91375345

Sponsors and Collaborators

Mashhad University of Medical Sciences

Investigators

Study Chair:	Arash Mansourian, DDS,MS	Tehran University of Medical Sciences
Study Director:	Majid Sanatkhani, DDS,MS	Mashhad University of Medical Sciences
Principal Investigator:	Fatemeh Momen Heravi	Tehran University of Medical Sciences

More Information

Related Info This link exits the ClinicalTrials.gov site

Study ID Numbers:	240
Study First Received:	June 7, 2007
Last Updated:	June 8, 2007
ClinicalTrials.gov Identifier:	NCT00484250
Health Authority:	Iran: Ministry of Health

Keywords provided by Mashhad University of Medical Sciences:

Oral Lichen Planus
Metronidazole
Doxycycline

Study placed in the following topic categories:

Mouth Diseases
Lichen Planus
Metronidazole
Exanthema
Skin Diseases

Oral lichen planus
Stomatognathic Diseases
Skin Diseases, Papulosquamous
Doxycycline
Lichen Planus, Oral

Additional relevant MeSH terms:

Antimalarials
Anti-Infective Agents
Anti-Bacterial Agents
Antiparasitic Agents
Antiprotozoal Agents

Radiation-Sensitizing Agents
Therapeutic Uses
Physiological Effects of Drugs
Lichenoid Eruptions
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 16, 2009