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Sponsored by: |
Hospices Civils de Lyon |
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Information provided by: | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00130767 |
The aim of this study is to evaluate the mechanisms involved in the apoptosis induced by a treatment of finasteride on benign prostate hyperplasia (BPH). Five sets of patients who need a surgical procedure because of low tract urinary symptoms are randomly attributed to one of five sets of treatment: 0, 7, 14, 21 or 28 days of finasteride treatment before the day of the procedure. Prostate histological fragments are conditioned for molecular and histologic studies.
Condition | Intervention | Phase |
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Benign Prostatic Hyperplasia |
Drug: finasteride |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Uncontrolled, Parallel Assignment |
Official Title: | Kinetics of the Finasteride Prostate Induced Apoptosis |
Estimated Enrollment: | 90 |
Study Start Date: | December 2004 |
Ages Eligible for Study: | 40 Years to 90 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Study ID Numbers: | 2003.316 |
Study First Received: | August 12, 2005 |
Last Updated: | April 26, 2007 |
ClinicalTrials.gov Identifier: | NCT00130767 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Prostate apoptosis finasteride kinetics |
Finasteride Hyperplasia Prostatic Diseases Prostatic Hyperplasia Genital Diseases, Male |
Pathologic Processes Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors Pharmacologic Actions |