Inclusion Criteria:

• Clinical diagnosis of a Depressive disorder (Diagnostic and Statistical Manual of Mental Disorders – IV-TR)
• Presence of excessive sweating by self-report
• The excessive sweating started after initiation of an antidepressant and, if treatment with the antidepressant was interrupted, did not persist for more than 4 weeks during that interruption
• Treatment with the antidepressant is deemed to be clinically necessary due to substantial benefit from this antidepressant, and failure to respond to or tolerate an alternative
• Excessive sweating has persisted for at least 4 weeks prior to baseline assessment
• The excessive sweating is rated by the patient as at least moderately bothersome.
• Episodes of excessive sweating occur at least twice a week for last 4 weeks

Exclusion Criteria:

• Presence of another known disease that could potentially cause excessive sweating
• Failure to respond to antiadrenergic (reducing activity of the sympathetic nervous system) treatment in the past
• Blood pressure less than 110 mm Hg systolic at the screening or baseline visits
• Orthostatic hypotension by history or on assessment at the screening or baseline visits (defined as a decrease of 10 mm Hg or greater after standing for 2 minutes).
• Current antihypertensive treatment
• History of significant cardiac disease, including coronary artery disease
• Current use of phosphodiesterase type 5 inhibitors: sildenafil (Viagra™), tadalafil (CialisTM), or vardenafil (LevitraTM)
• History of priapism (persistent and painful erection)