Inclusion Criteria:

• Subjects must demonstrate their willingness to participate in the study and comply with its procedures by signing a written informed consent.
• Subjects must be 18 to 65 years of age.
• Subjects must be between 40 and 125 kg.
• HCV genotype 1 (including mixtures of subtypes of genotype 1).
• Naïve to interferon (any formulation) and ribavirin.
• Serum TNF-alpha >300 pg/mL(single measure at screening ).
• HCV ribonucleic acid (RNA) positive.
• Any alanine aminotransferase (ALT) level.
• Prior to Screening Visit, Fasting glucose should be 3.8-6.2 mmol/L. Results between 6.3-7.8 mmol/L require a HbA1c <=8.5%. All diabetic subjects must have an HbA1c <=8.5%, whether on medication or diet controlled.
• Liver biopsy within 24 months of enrolment demonstrating Stage 1-3 fibrosis (Metavir System).

• Compensated liver disease with the following minimum hematological, biochemical, and serological criteria at the screen visit (WNL = within normal limits):

  • Hemoglobin values of equal or more than 12 g/dL for females and 13 g/dL for males.
  • White blood cell (WBC) count equal to or more than 3,000/mm**3
  • Neutrophil count equal to or more than 1,500/mm**3
  • Platelet count equal to or more than 80,000/mm**3
  • Total bilirubin WNL
  • Indirect bilirubin WNL (unless non-hepatitis related factors such as Gilbert's disease explain an indirect bilirubin rise). In such cases indirect bilirubin should be less than or equal to 50 µmol/L
  • Albumin WNL
  • Serum creatinine WNL
• Women of childbearing potential (includes women who are less than 1 year postmenopausal and women who become sexually active) must be willing to use an acceptable method of birth control, deemed acceptable by the investigator, (e.g., hormonal contraceptive, medically prescribed intrauterine device (IUD), condom in combination with spermicidal) or be surgically sterilized (e.g., hysterectomy or tubal ligation).
• Subjects must understand and be able to adhere to the dosing and visit schedules, and agree to record, study medication compliance, concomitant medications, and adverse events accurately and consistently in a daily diary.

Exclusion Criteria:

• Women who are pregnant or nursing.
• Subjects who have not observed the designated washout periods for any of the prohibited medications.
• Subjects who have used any investigational product within 30 days prior to enrollment.
• Acute HCV infection defined as infection for <12 months.
• Male partners to/or Heterosexually active women of childbearing potential not practicing a highly effective form of contraception.
• Positive screening for tuberculosis (TB) or Mantoux > 5mm.
• Cirrhotics (Stage 4 on Metavir System).
• Active hepatitis B virus (HBV) infection (hepatitis B surface antigen [HBsAg] positive).

• Any known pre-existing psychiatric condition that could interfere with the subject's participation in and completion of the study such as:

  • Pre-existing psychiatric condition, including but not limited to moderate to severe depression, or a history of severe psychiatric disorders, such as psychosis, suicidal ideation and/or suicidal attempt

  • Severe depression includes the following:

    • Hospitalization for depression,
    • Electro convulsive therapy for depression, or
    • Depression that resulted in a prolonged absence from work and/or significant disruption of daily functions.
• Subjects with uncontrolled hypertension and/or diabetes.
• Alcohol consumption >50 g/day.
• Nonprescription injection drug use in past 6 months.
• HIV antibody positive.
• Previous Infliximab or other anti-TNF treatment, previous interferon; Pegylated interferon alfa-2b and ribavirin of any form.
• Clinically significant impairment in cardiac or renal function, central nervous system, pulmonary, immunological, vascular and gastrointestinal disease.
• Current malignancy (other than resected cutaneous basal, squamous cell carcinoma and/or in situ cervical cancer).
• Use of illicit drugs which, in the investigator's opinion, may interfere with compliance with the study procedures.
• Any medical conditions which, in the investigator's opinion, may interfere with the evaluation of the trial medication.
• Have shown a previous immediate hypersensitivity response, including anaphylaxis, to an immunoglobulin product (plasma-derived or recombinant, e.g., monoclonal antibody).
• Have a known allergy to murine proteins or other chimeric proteins.
• Have or have had any of the following infections within 6 months of screening: herpes zoster [shingles], cytomegalovirus, Pneumocystis carinii, aspergillosis, histoplasmosis, or mycobacteria other than TB.
• Have a transplanted organ (with the exception of a corneal transplant performed > 3 months prior to screening).
• Have a concomitant diagnosis or any history of congestive heart failure (CHF).
• History of noncompliance to medical regimens, or other condition/circumstance that could interfere with the patient's adherence to protocol requirements (e.g., psychiatric disease, lack of motivation, travel, etc).

• Any cause of liver disease other than chronic hepatitis C, including but not limited to:

  • Hemochromatosis
  • Alpha-1 antitrypsin deficiency
  • Wilson's disease
  • Autoimmune hepatitis
  • Alcoholic liver disease
  • Non-alcoholic steatohepatitis (NASH)
  • Drug-related liver disease
• Subjects weigh <40kg and >125kg will be excluded.