Inclusion Criteria:

1. Pathologic diagnosis of colorectal cancer.
2. Clinical and/or radiologic evidence of metastatic disease.
3. One previous systemic treatment for metastatic disease.
4. Age > 18.
5. Presence of at least one measurable lesion.
6. Adequate hematopoetic (absolute neutrophil count > 1500/mm3, platelet count > 100,000/mm3), renal (serum creatinine < 1.5 mg/dl), and hepatic function (bilirubin < 1.5 and transaminases < 5.0 x upper normal limit).
7. ECOG performance status 0-2.
8. Life expectancy > 3 months.
9. Patients must be informed of the investigational nature of this study and provide written informed consent in accordance with the institutional and federal guidelines prior to the initiation of therapy.

Exclusion Criteria:

1. No recognized brain metastasis.
2. No previous treatment with mitomycin C or cetuximab.
3. No other systemic malignancy requiring treatment within the past one year.
4. Pregnant or lactating women may not participate. Women/men of reproductive potential must agree to use an effective contraceptive method.
5. Patients must have no other serious medical or psychiatric illness that would limit the ability of the patient to receive protocol therapy or provide informed consent.