Inclusion Criteria:

• The subject is ≥ 18 years old;
• Subject is eligible for percutaneous coronary intervention (PCI), stent placement, and emergent coronary artery bypass graft (CABG) surgery;
• Subject has clinical evidence of ischemic heart disease, stable or unstable angina or silent ischemia;
• The subject has a documented left ventricular ejection fraction (LVEF) ≥ 30%;
• The subject or legal representative has been informed of the clinical study and the required follow-up procedures and must provide written informed consent using a form that is reviewed and approved by the Institutional Review Board/Ethics Committee (IRB/EC) for the clinical site;
• Female subjects of childbearing potential must have a negative pregnancy test within 7 days before treatment;
• Subject must agree to comply with the required follow-up procedures (including antiplatelet regimen) to the best of their ability, be geographically available for all study follow-up procedures and visits and not have a known medical condition that precludes completion of the required follow-up visits;
• The lesion is either de novo or restenotic (previously unstented) in nature, located in a native coronary artery AND is ≥ 50% and < 100% stenosed by visual estimate or on-line QCA;
• The target vessel reference diameter ≥ 2.5mm and ≤ 4mm by visual estimate and is appropriate for treatment with available stent diameters of 2.5 mm, to 4.0 mm;
• The lesion length is ≤ 26 mm and able to accommodate placement of a single stent;
• The target lesion is a minimum of 15 mm from any previously placed stent; AND
• The target vessel must have a Thrombolysis In Myocardial Infarction (TIMI) flow ≥ 2

Exclusion Criteria:

• The subject has a known hypersensitivity or contraindication to aspirin, heparin and bivalirudin, ticlopidine and clopidogrel, cobalt, nickel, chromium, molybdenum, or a sensitivity to contrast media, which cannot be adequately pre-medicated;
• A platelet count < 100,000 cells/mm³ or > 700,000 cells/mm³, or a WBC < 3,000 cells/mm³;
• A creatinine level > 2.5 mg/dL within 7 days prior to the index procedure;
• Evidence of an acute myocardial infarction (MI) within 72 hours of the intended treatment (defined as: Q wave (QWMI) or any elevation of creatine kinase myocardial-band (CK-MB) isoenzyme elevated above the Institution's upper limit of normal;
• Any previous PCI (with or without stent) of the target vessel within 30 days prior to the index procedure;
• Previous stent placement anywhere in the target lesion;
• Previous drug eluting stent (DES) deployment anywhere in the target vessel;
• The subject requires staged procedure of any non-target vessel within 30 days post-procedure;
• The subject requires staged procedure of the target vessel within 9 months post-procedure;
• The target lesion requires treatment with a device other than PTCA prior to stent placement (including, but not limited to, cutting balloon, directional coronary atherectomy, excimer laser, rotational atherectomy, thrombectomy, etc.;
• History of a stroke or transient ischemic attack (TIA) within the previous 6 months;
• Active peptic ulcer or upper gastrointestinal (GI) bleeding within the previous 6 months;
• History of bleeding diathesis or coagulopathy or will refuse blood transfusions;
• A known concurrent medical condition resulting in a life expectancy of less than 12 months;
• Any previous or planned treatment of the target vessel with anti-restenotic therapies including, but not limited to brachytherapy;
• The subject is currently participating in another investigational device or drug study and has not completed the primary endpoint(s) follow-up phase of that study at least 30 days prior to enrollment in this trial; or interferes with the current trial endpoints; or the subject has previously been enrolled in the study;
• The subject has a known medical condition that will cause them to be non-compliant with the study protocol or confound the data interpretation;
• The target vessel has evidence of thrombus or other lesions having a > 60% stenosis by visual estimate or on-line QCA;
• Target vessel exhibiting multiple lesions with greater than 60% diameter stenosis outside of a range of 5 mm proximal and distal to the target lesion based on visual estimate or on-line QCA;
• The target vessel has evidence (visual or QCA) of excessive tortuosity (two or more 90° bends prior to the target lesion) or is severely calcified; OR
• The target lesion is in an unprotected left main, involves a side branch vessel having a diameter of > 2.0 mm or is at the aorto-ostial location