Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
University of Wisconsin, Madison National Institutes of Health (NIH) National Institute on Aging (NIA) |
---|---|
Information provided by: | University of Wisconsin, Madison |
ClinicalTrials.gov Identifier: | NCT00478491 |
The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.
Condition |
---|
Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease |
plasma and serum
Estimated Enrollment: | 390 |
Study Start Date: | January 2003 |
Estimated Study Completion Date: | July 2009 |
Groups/Cohorts |
---|
1
Persons with a parent with Alzheimer's disease
|
2
Persons whose parents survived to old age without memory problems
|
3
Persons with diagnosed mild cognitive impairment
|
4
Persons without memory problems
|
Ages Eligible for Study: | 40 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Persons with a parent with Alzheimer's disease will be recruited from the Wisconsin Registry for Alzheimer's Prevention (WRAP). Persons with MCI will be recruited from the UW clinics and satellite clinics. Controls for the above study groups will be recruited from the WRAP and the local community.
Inclusion Criteria:
Exclusion Criteria:
United States, Wisconsin | |
University of Wisconsin - Wisconsin Comprehensive Memory Program | |
Madison, Wisconsin, United States, 53792 |
Principal Investigator: | Sterling C Johnson, PhD | University of Wisconsin/VA GRECC |
Responsible Party: | University of Wisconsin - Madison ( Sterling Johnson, PhD ) |
Study ID Numbers: | 2002-515, NIH RO1 AG021155A |
Study First Received: | May 22, 2007 |
Last Updated: | November 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00478491 |
Health Authority: | United States: Institutional Review Board |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Alzheimer Disease Central Nervous System Diseases Neurodegenerative Diseases |
Brain Diseases Dementia Cognition Disorders Delirium |
Nervous System Diseases Tauopathies |