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Sponsors and Collaborators: |
University of Wisconsin, Madison Department of Veterans Affairs |
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Information provided by: | University of Wisconsin, Madison |
ClinicalTrials.gov Identifier: | NCT00478400 |
This study will use MRI imaging, cognitive testing and outcome questionnaires to determine how the brain recovers and reorganizes after an injury.
Condition |
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Traumatic Brain Injury Veterans |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | Awareness of Deficit After Combat-Related Brain Injury |
Estimated Enrollment: | 100 |
Study Start Date: | October 2007 |
Estimated Study Completion Date: | September 2010 |
Groups/Cohorts |
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1
Persons who have had a traumatic brain injury (recruited by invitation only)
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Persons who have no history of brain injury (recruited by invitation only)
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US Veterans who have had a traumatic brain injury within 6 years
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US Veterans who have no history of brain injury.
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The extent of recovery from brain injury is often difficult to predict because of our limited understanding of how the brain changes as it heals. New brain imaging methods may help in this regard. One imaging technique called functional magnetic resonance imaging (fMRI) has made it possible to study the brain "at work"; that is, we can see regions of the brain that are active during particular tasks such as focusing attention, making decisions, or remembering words and pictures. Another MRI method called diffusion tensor imaging provides information on the pathways between brain regions that may be altered with brain injury.
The goals of this research are to 1) determine the brain regions involved in making accurate judgments about one's abilities and disabilities after a brain injury and whether damage to these brain areas affects outcome; and 2) examine how recovery of cognitive and physical abilities relates to changes in brain function over time. In order to accomplish the first goal we will recruit Veterans who have sustained a head injury and matched control subjects. For the second goal, we are asking patients and controls who have previously participated in brain injury research with our lab to come back for another visit at three years post-injury.
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Veterans will be recruited through the Middleton VA Hospital in Madison, WI. Civilian participants will be recruited from a previous study led by Dr. Johnson.
Inclusion Criteria:
Exclusion Criteria:
Contact: Amy Hawley, BA | 608-256-1901 ext 11418 | fmri@medicine.wisc.edu |
Contact: Sandy Harding, MS | 608-256-1901 ext 11075 | fmri@medicine.wisc.edu |
United States, Wisconsin | |
University of Wisconsin - Wisconsin Comprehensive Memory Program | Recruiting |
Madison, Wisconsin, United States, 53792 | |
Contact: Tamara S Markgraf 866-636-7764 memory-research@medicine.wisc.edu | |
Principal Investigator: Sanjay Asthana, MD |
Principal Investigator: | Sterling C Johnson, PhD | University of Wisconsin/VA GRECC |
Responsible Party: | University of Wisconsin - Madison ( Sterling Johnson, PhD ) |
Study ID Numbers: | 2006-0256, VA Merit Grant |
Study First Received: | May 22, 2007 |
Last Updated: | November 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00478400 |
Health Authority: | United States: Institutional Review Board; United States: Veterans Administration |
Recovery Magnetic resonance imaging Awareness Neurologic deficits |
Craniocerebral Trauma Wounds and Injuries Disorders of Environmental Origin Central Nervous System Diseases |
Trauma, Nervous System Brain Diseases Brain Injuries |
Nervous System Diseases |