|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||
| Sponsored by: |
Centro Cardiologico Monzino |
|---|---|
| Information provided by: | Centro Cardiologico Monzino |
| ClinicalTrials.gov Identifier: | NCT00517725 |
Purpose
We test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.
Both could influence exercise capacity in normoxic as well as hypoxic conditions.
| Condition | Intervention | Phase |
|---|---|---|
|
Chronic Heart Failure |
Drug: carvedilol Drug: bisoprolol Drug: Nebivolol |
Phase IV |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Single Blind (Investigator), Active Control, Crossover Assignment, Efficacy Study |
| Official Title: | Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function |
| Estimated Enrollment: | 60 |
| Study Start Date: | July 2007 |
| Estimated Study Completion Date: | August 2009 |
| Arms | Assigned Interventions |
|---|---|
| Carvedilol: Active Comparator | Drug: carvedilol |
| Bisoprolol: Active Comparator | Drug: bisoprolol |
| Nebivolol: Active Comparator | Drug: Nebivolol |
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Piergiuseppe Agostoni, MD, PhD | +39.025800 ext 2299 | piergiuseppe.agostoni@ccfm.it |
| Italy | |
| Centro Cardiologico Monzino, University of Milan | Recruiting |
| Milan, Italy, 20138 | |
| Contact: Piergiuseppe Agostoni, MD, PhD +39.025800 ext 2299 piergiuseppe.agostoni@ccfm.it | |
| Principal Investigator: | Piergiuseppe Agostoni, MD, PhD | Centro Cardiologico Monzino |
| Study Chair: | Giancarlo Marenzi, MD | Centro Cardiologico Monzino |
More Information
| Study ID Numbers: | R76-CCM S78/407 |
| Study First Received: | August 16, 2007 |
| Last Updated: | August 16, 2007 |
| ClinicalTrials.gov Identifier: | NCT00517725 |
| Health Authority: | Italy: Ministry of Health |
|
exercise lung diffusion hypoxia |
chemoreceptor beta-blockers heart failure |
|
Bisoprolol Heart Failure Heart Diseases Nebivolol Carvedilol |
|
Vasodilator Agents Neurotransmitter Agents Sympatholytics Adrenergic Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Adrenergic alpha-Antagonists Cardiovascular Agents |
Antihypertensive Agents Pharmacologic Actions Autonomic Agents Therapeutic Uses Adrenergic beta-Antagonists Cardiovascular Diseases Adrenergic Antagonists Peripheral Nervous System Agents |
