Retinal Nerve Fiber Layer Thickness Measurement on Parapapillary Atrophy With the Cirrus High-Definition (HD) Optical Coherence Tomography (OCT) - Full Text View

Sponsored by:	Yonsei University
Information provided by:	Yonsei University
ClinicalTrials.gov Identifier:	NCT00742196

Purpose

Retinal nerve fiber layer (RNFL) thickness measurement on the parapapillary atrophy is incorrect. Because a new spectral domain OCT, the Cirrus HD OCT, uses a movable circle to analyze the RNFL thickness, we may suggest a new analysis strategy for the parapapillary atrophy.

Condition
Glaucoma

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Retrospective
Official Title:	Retinal Nerve Fiber Layer Thickness Measurement on Parapapillary Atrophy With

Further study details as provided by Yonsei University:

Primary Outcome Measures:

Retinal nerve fiber layer thickness [ Time Frame: when the OCT images are taking ] [ Designated as safety issue: No ]
Size of parapapillary atrophy [ Time Frame: when the OCT images are taking ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	30
Study Start Date:	September 2008
Estimated Study Completion Date:	March 2009
Estimated Primary Completion Date:	December 2008 (Final data collection date for primary outcome measure)

Groups/Cohorts
1 No parapapillary atrophy
2 Parapapillary atrophy

Detailed Description:

Recently, the retinal nerve fiber layer (RNFL) thickness measurement using the optical coherence tomography (OCT) becomes very useful to detect such a glaucomatous damage. However, there are some difficult cases including parapapillary atrophy to perform this measurement. Because the RNFL thickness is so sensitive to the position of measurement and the measurement of RNFL thickness on parapapillary atrophy is incorrect, it is difficult to determine exact RNFL thickness in patients with a large parapapillary atrophy. In the present study, we want to find the proper method to analyze the RNFL thickness on parapapillary atrophy. The previous OCT used a fixed circle to measure the RNFL thickness, but the new spectral domain OCT, the Cirrus HD OCT, uses a movable one. Therefore, we may suggest a new analysis strategy for the parapapillary atrophy.

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Subjects with or without parapapillary atrophy

Criteria

Inclusion Criteria:

Qualified OCT images (signal strength > or = 8)

Exclusion Criteria:

Previous intraocular surgery history
Media opacity
DM

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00742196

Contacts

Contact: Gong Je Seong, MD, PhD

82-2-2019-3441

gjseong@yuhs.ac

Locations

Korea, Republic of
Gong Je Seong
Seoul, Korea, Republic of, 135-720

Sponsors and Collaborators

Yonsei University

Investigators

Principal Investigator:

Gong Je Seong, MD, PhD

Yonsei University College of Medicine

More Information

Responsible Party:	Yonsei University College of Medicine ( Gong Je Seong )
Study ID Numbers:	3-2008-0076-2
Study First Received:	August 26, 2008
Last Updated:	August 26, 2008
ClinicalTrials.gov Identifier:	NCT00742196
Health Authority:	Korea: Food and Drug Administration

Keywords provided by Yonsei University:

Parapapillary atrophy
Retinal nerve fiber layer thickness
Glaucoma
Cirrus OCT

Study placed in the following topic categories:

Pathological Conditions, Anatomical
Glaucoma
Eye Diseases

Atrophy
Hypertension
Ocular Hypertension

ClinicalTrials.gov processed this record on January 16, 2009