Inclusion Criteria:

• Male and female patients between 18 and 65 years of age
• Anti-HCV positive
• Detectable plasma HCV-RNA
• Relapsers after treatment with interferon o peginterferon +/- ribavirin
• HIV positive
• CD4 >/= 200 cell
• Patients on clinically stable liver disease with:

Hgb >/= 12 g/dL in women or 13 g/dL in men Leucocytes >/= 3000 mm3 Neutrophil count (ANC) >/= 1500 cells/mm3 Platelet count >/= 100.000 cells/mm3 Normal prothrombin, bilirubin, albumin, creatinine and uric acid

• HBsAg negative
• With antecedents of diabetes or hypertension is necessary an previous ocular exploration

Exclusion Criteria:

• Women with ongoing pregnancy or breast feeding
• Positive test at screening for anti-HAV IgM Ab, HBsAg, anti-HBc IgM Ab, HBeAg
• Hemochromatosis
• Deficit of alfa-1 antitrypsin
• Wilson disease
• Alcoholic liver disease
• Autoimmune hepatitis
• Hepatitis by toxin exposures
• Hepatitis by obesity
• Hemoglobinopathy (e.g. thalassemia)
• History or other evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease
• Hepatocarcinoma observed in the liver ecography.
• History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or a major tranquilizer at therapeutic doses for major depression or psychosis, respectively, for at least 3 months at any previous time or any history of the following: a suicidal attempt, hospitalization for psychiatric disease, or a period of disability due to a psychiatric disease
• History of a severe seizure disorder or current anticonvulsant use
• History of significant cardiac disease that could be worsened by acute anemia (e.g. NYHA Functional Class III or IV, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina)
• Diabetes Mellitus
• History of immunologically mediated disease (e.g., inflammatory bowel disease, idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, rheumatoid arthritis)
• History or other evidence of chronic pulmonary disease associated with functional limitation
• Drug use within 6 months of 1st dose and excessive alcohol consumption.
• Concomitant treatment with ddI
• Male partners of women who are pregnant