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Sponsors and Collaborators: |
University Hospital, Gentofte, Copenhagen University of Copenhagen |
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Information provided by: | University Hospital, Gentofte, Copenhagen |
ClinicalTrials.gov Identifier: | NCT00638573 |
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question we plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.
Condition |
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Chronic Pancreatitis Type 2 Diabetes Mellitus |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | The Incretin Effect in Patients With Chronic Pancreatitis With and Without Secondary Diabetes Mellitus |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Denmark, Copenhagen County | |
Gentofte University Hospital | |
Hellerup, Copenhagen County, Denmark, 2900 |
Principal Investigator: | Filip K Knop, MD | University of Copenhagen |
Study Director: | Jens J Holst, MD DMSc | University of Copenhagen |
Study Director: | Thure Krarup, MD DMSc | Gentofte University Hospital |
Study ID Numbers: | KA04034 |
Study First Received: | March 12, 2008 |
Last Updated: | March 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00638573 |
Health Authority: | Denmark: National Board of Health |
Digestive System Diseases Metabolic Diseases Diabetes Mellitus, Type 2 Diabetes Mellitus Neoplasm Metastasis Pancreatic Diseases |
Endocrine System Diseases Endocrinopathy Metabolic disorder Glucose Metabolism Disorders Pancreatitis Pancreatitis, Chronic |