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Sponsored by: |
Penn State University |
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Information provided by: | Penn State University |
ClinicalTrials.gov Identifier: | NCT00219492 |
Chest pain is a common clinical complaint. About 30% patients with chest pain will have a normal coronary angiogram and are described as having noncardiac chest pain (NCCP). It is estimated that 25% of the population complain of chest pain at some time in their lifetime. The pathogenesis of NCCP is unknown. Esophageal hypersensitivity as a result of inflammation is considered to be an important mechanism in the development of this pain sensation. Little is currently known about the interaction between inflammatory mediators and peripheral afferent nerve terminals in the esophagus. The mast cell is one of the most enriched pro-inflammatory cells in the gastrointestinal tract. Activation of the mucosal mast cell releases a variety of mediators into adjacent tissues. We hypothesize that mediators released by mast cells sensitize esophageal nociceptors and induce pain sensation.
Condition |
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Noncardiac Chest Pain (NCCP) |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Official Title: | Role of Esophageal Mast Cell Activation in Noncardiac Chest Pain (NCCP) |
Estimated Enrollment: | 90 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | September 2008 |
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
- History of ischemic heart disease, history of asthma, significant food allergies, celiac disease, chronic inflammatory conditions (SLE, rheumatoid arthritis), atopic skin disease, varices, coagulopathy, recent drug treatment with steroids.
Contact: Shaouyong Yu, MD, MPH | 717-531-4466 | suy13@psu.edu |
Contact: Ann Ouyang, MD | 717-531-8741 | aouyang@psu.edu |
United States, Pennsylvania | |
Penn State College of Medicine Hershey Medical Center | Recruiting |
Hershey, Pennsylvania, United States, 17033 | |
Contact: Kathyrn Kaylor 717-531-4466 kkaylor@psu.edu | |
Principal Investigator: Shaoyong Yu, MD, MPH | |
Sub-Investigator: Ann Ouyang, MD |
Principal Investigator: | Shaoyong Yu, MD, MPH | Department of Medicine, Penn State College of Medicine Hershey Medical Center |
Study Director: | Ann Ouyang, MD | Penn State College of Medicine Hershey Medical Center |
Study ID Numbers: | 21370 |
Study First Received: | September 16, 2005 |
Last Updated: | September 16, 2005 |
ClinicalTrials.gov Identifier: | NCT00219492 |
Health Authority: | United States: Institutional Review Board |
NCCP, mast cell, esophagus |
Signs and Symptoms Esophageal disorder Pain Esophageal Diseases Chest Pain |