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Sponsors and Collaborators: |
National Institute on Drug Abuse (NIDA) Yale University University of Arkansas |
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Information provided by: | National Institute on Drug Abuse (NIDA) |
ClinicalTrials.gov Identifier: | NCT00218608 |
Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect. Cocaine users are at risk for many health problems, both directly and indirectly related to the effects of cocaine. Disulfiram, a drug used to treat chronic alcoholism, may be effective in reducing cocaine use. This study will evaluate the effectiveness of three different doses of disulfiram in treating cocaine dependence in opioid- and cocaine-dependent individuals maintained on methadone.
Condition | Intervention | Phase |
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Cocaine-Related Disorders Opioid-Related Disorders |
Drug: Disulfiram |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Disulfiram for Cocaine Abuse in Methadone- Patients |
Enrollment: | 158 |
Study Start Date: | April 2001 |
Study Completion Date: | January 2007 |
Despite the harm that cocaine can cause to the body, its abuse is widespread. It is the cause of more visits to hospital emergency rooms nationwide than any other illegal drug. Effective treatments for cocaine and opiate addictions are essential to the decline of cocaine- and opiate-related disorders. Unfortunately, cocaine use remains prevalent among participants in many opioid maintenance programs. The addition of other medications to methadone maintenance may prove helpful in reducing cocaine use. Disulfiram, a drug used to treat chronic alcoholism, causes unpleasant effects when even small amounts of alcohol are consumed. This study will evaluate the effectiveness of three different doses of disulfiram in treating cocaine dependence in opioid- and cocaine-dependent individuals maintained on methadone.
Participants in this double blind study will be randomly assigned to receive either disulfiram at one of three dosage levels (62.5, 125, 250 mg/day) or placebo for 14 weeks. During the first 2 weeks, doses of methadone plus either disulfiram or placebo will be administered until the assigned maintenance dose is achieved. This dosage level will be maintained for the duration of the study. Participants will be required to report to the study site Monday through Saturday of each week for assessments and to receive medication. They will receive a take-home dose of medication for Sunday. In addition, participants will receive a weekly session of cognitive-behavioral therapy. Urine samples will be collected three times a week to assess drug use. At the end of the study, participants will undergo a 4- to 6-week detoxification period in which they will gradually discontinue the use of methadone and disulfiram. All participants have the option to request transfer to a local methadone maintenance program instead of undergoing detoxification.
Enrollment has been completed and no subjects are active. Data analyses are being conducted at this time.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Arkansas | |
University of Arkansas for Medical Sciences | |
Little Rock, Arkansas, United States, 72205 7911 |
Principal Investigator: | Alison Oliveto, PhD | UAMS |
Study ID Numbers: | NIDA-13441-1, R01-13441-1, DPMC |
Study First Received: | September 20, 2005 |
Last Updated: | May 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00218608 |
Health Authority: | United States: Federal Government |
Cocaine Abuse |
Disulfiram Cocaine-Related Disorders Methadone Dopamine Mental Disorders |
Substance-Related Disorders Disorders of Environmental Origin Cocaine Opioid-Related Disorders Ethanol |
Dopamine Uptake Inhibitors Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Disease Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Central Nervous System Depressants Anesthetics Enzyme Inhibitors Cardiovascular Agents |
Pharmacologic Actions Anesthetics, Local Pathologic Processes Sensory System Agents Therapeutic Uses Vasoconstrictor Agents Dopamine Agents Peripheral Nervous System Agents Central Nervous System Agents Alcohol Deterrents |