Inclusion Criteria:

• Relapsed or refractory Hodgkin's disease with a minimum of 2 prior treatment regimens, including autologous bone marrow transplantation.
• Must have histologically proven diagnosis of nodular sclerosis or mixed cellularity Hodgkin's disease.
• Hodgkin's lymphoma should be limited to lymph nodes, spleen, and bone marrow.
• Must have bi-dimensionally measurable disease defined as a lymph node at least 2 cm by computed tomography (CT) scan.
• Platelet count equal to or greater than 50,000/uL; absolute neutrophil count equal to or greater than 1,000/uL.
• Must sign a consent form.
• Males or females equal to or greater than 18 years of age.
• Patients may be taking voriconazole, itraconazole, or diflucan.

Exclusion Criteria:

• No serious inter-current infections requiring therapy.
• No Hodgkin-specific therapy within the last 3 weeks.
• Pregnant women and women of childbearing potential and men of reproductive potential who are not practicing adequate contraception.
• Lymphocyte depletion or lymphocyte predominance histology.
• History of HIV infection.
• Central nervous system (CNS) involvement with lymphoma including epidural disease and cord compression.
• Prior allogeneic stem cell transplantation.
• Patients receiving steroids within 3 weeks of registration.
• Patients with a history of prior severe opportunistic infections that are controlled by T-cell immunity, such as pneumocystis pneumonia (PCP), herpes virus infections, mycobacterial disease, invasive mold infections or endemic fungi.
• Patients with an ejection fraction of less than 40%.