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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00108173 |
The purpose of the study is to determine how the treatments for cigarette craving work.
Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.
Condition | Intervention | Phase |
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Nicotine Dependence |
Drug: Zyban |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Pharmacokinetics/Dynamics Study |
Official Title: | Neural Substrates of Treatment for Nicotine Dependence |
Ages Eligible for Study: | 21 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Study ID Numbers: | ADRD-018-02S |
Study First Received: | April 14, 2005 |
Last Updated: | March 27, 2008 |
ClinicalTrials.gov Identifier: | NCT00108173 |
Health Authority: | United States: Federal Government |
Nicotine dependence Position Emission Tomography (PET) drug craving practical group counseling |
Nicotine polacrilex Nicotine Mental Disorders Tobacco Use Disorder |
Bupropion Substance-Related Disorders Disorders of Environmental Origin |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cholinergic Agonists Autonomic Agents Nicotinic Agonists |
Physiological Effects of Drugs Ganglionic Stimulants Peripheral Nervous System Agents Cholinergic Agents Pharmacologic Actions |