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Sponsors and Collaborators: |
Bayside Health The Alfred |
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Information provided by: | Bayside Health |
ClinicalTrials.gov Identifier: | NCT00163696 |
The researchers are investigating a novel technique, the multi breath nitrogen washout technique, to measure airway changes in various respiratory diseases.
Condition |
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Cystic Fibrosis Asthma Bronchiolitis Obliterans Lung Transplantation |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Measurements of Inhomogeneity of the Small Airway With Patients With Cystic Fibrosis, Asthma and Bronchiolitis Obliterans Syndrome (Post Transplant) Using the Multi Breath Nitrogen Washout Technique |
Estimated Enrollment: | 90 |
Study Start Date: | September 2004 |
It is well documented that there are significant ventilatory changes in respiratory diseases such as cystic fibrosis, asthma and the onset of bronchiolitis obliterans syndrome (BOS) following chronic rejection of lung transplantation. At present, we use measures such as spirometry and lung biopsies to determine the changes of airway function and disease severity. Our aim is to develop a novel technique called the multi breath nitrogen washout (MBNW) which we believe is able to measure the inhomogeneity of ventilation in both the larger airways (conductive region, generation 1 - 16) as well as the smaller airways (acinar region 17 - 23). Our belief is that these measurements are much more subtle than current techniques and will be more sensitive in measuring large and small airway changes in disease. The MBNW can also give us an insight as to which particular zones of the lung are affected in differing respiratory disease. For example, it is believed that BOS begins at the distal portion of the lung (acinar region) and proceeds towards the proximal zone (conductive). However, at present no current techniques can differentiate between damage to the acinar zone and the conductive zone or indeed accurately measure small airway (acinar zone) function. We believe the the MBNW has the capacity to do so.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Bruce Thompson | ++61 3 9276 3476 | b.thompson@alfred.org.au |
Australia, Victoria | |
Alfred Hospital | Recruiting |
Melbourne, Victoria, Australia, 3004 | |
Contact: Bruce Thompson ++61 3 9276 3476 b.thompson@alfred.org.au |
Principal Investigator: | Bruce Thompson | Head of Physiology Services, Alfred Hospital |
Study ID Numbers: | MBNW alfred |
Study First Received: | September 11, 2005 |
Last Updated: | July 25, 2007 |
ClinicalTrials.gov Identifier: | NCT00163696 |
Health Authority: | Australia: National Health and Medical Research Council |
MBNW Ventilation small airways Lung Transplant recipients (Bronchiolitis Obliterans syndrome) |
Lung Diseases, Interstitial Fibrosis Bronchiolitis Respiration Disorders Asthma Bronchiolitis Obliterans Lung Diseases, Obstructive Hypersensitivity Digestive System Diseases Genetic Diseases, Inborn |
Respiratory Tract Infections Cystic Fibrosis Respiratory Tract Diseases Lung Diseases Hypersensitivity, Immediate Infant, Newborn, Diseases Pancreatic Diseases Bronchitis Cystic fibrosis Respiratory Hypersensitivity |
Pathologic Processes Immune System Diseases Bronchial Diseases |