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Sponsored by: |
National Eye Institute (NEI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00076271 |
This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute (NEI) to learn more about the course of various pediatric, genetic, developmental, and eye movement diseases thorough long-term observation and treatment. It will also serve as the first step in determining the eligibility of patients who may wish to enroll in other NEI clinical research studies or undergo standard eye treatments.
Children with eye conditions, especially inherited or developmental conditions, and adults with eye disorders that began in childhood or that likely have a genetic or developmental component may be eligible for this study. Participants will undergo some or all of the following procedures:
Participants are followed up to 6 times a year for 3 years, depending on the diagnosis and treatment.
Condition |
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Eye Diseases |
Study Type: | Observational |
Official Title: | Evaluation and Treatment of Pediatric, Developmental and Genetic Eye Diseases |
Estimated Enrollment: | 350 |
Study Start Date: | January 2004 |
Estimated Study Completion Date: | October 2008 |
The purpose of this protocol is to allow the pediatric ophthalmology, genetic ophthalmology, and ocular motility specialists at the National Eye Institute to gain additional knowledge of the course of various pediatric, genetic, developmental and ocular motility diseases. Heretofore, this spectrum of diseases will be referred to as pediatric ophthalmology diseases. We wish to evaluate the effects of standard treatments for these diseases, use non- or minimally-invasive technologies to understand the pathogenesis of these diseases, and to collect blood or other easily obtained biologic sample (e.g., urine, saliva, hair, cheek swab, or stool) for future laboratory studies on these diseases. The information gained from this protocol will also allow for the maintenance of populations of patients with specific pediatric eye diseases and strabismus that may be eligible for future protocols. In addition, by allowing for the care of patients with a spectrum of these diseases, the protocol will be valuable for the training of pediatric eye disease, ocular genetics, and ocular motility fellows. The pediatric, genetic, and eye movement specialists at the National Eye Institute will choose ophthalmology diseases based on the training and research needs of the NEI program. While the primary focus of this protocol is to study eye disease in children, adults who have a disease that began in childhood or who may have an inherited eye disease or are unaffected first-degree relatives may also be evaluated under this protocol.
This protocol is not designed to test any new treatments. Any evaluation of treatments under this protocol will be based on the standard-of-care for each patient's disease. All alternatives for evaluation and care will be reviewed with each patient and the patient's family.
Patients in this evaluation and treatment protocol will be evaluated for potential eligibility in any new NEI clinical trials or epidemiological protocols as they are developed. If eligible, patients may be asked to participate in a new protocol. However, they will not be required to enter any new protocol and their decision to participate will be entirely voluntary.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Subjects will be able to enroll if they:
EXCLUSION CRITERIA:
Subjects will not be eligible if they:
United States, Colorado | |
Rocky Mountain Lions Eye Institute | |
Denver, Colorado, United States | |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 040039, 04-EI-0039 |
Study First Received: | January 16, 2004 |
Last Updated: | October 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00076271 |
Health Authority: | United States: Federal Government |
Strabismus Cataract, Pediatric Optic Nerve Anomaly Coloboma Evaluation and Treatment Pediatric Ophthalmology Genetic Eye Disease Nystagmus |
Pediatric Eye Disease Genetic Eye Disease Developmental Eye Condition Strabismus Cataract Juvenile Glaucoma Eye Movement Disorder |
Hydrophthalmos Ocular Motility Disorders Glaucoma Movement Disorders Eye Diseases Cataract |
Strabismus Glaucoma, congenital Congenital Abnormalities Ocular motility disorders Coloboma Nystagmus, Pathologic |