RNA Brain Maps
 


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Air date: Monday, December 17, 2007, 12:00:00 PM
Category: Neuroscience
Runtime: 75 minutes
NLM Title: RNA brain maps [electronic resource] / Robert Darnell.
Series: NIH neuroscience seminar series
Author: Darnell, Robert.
National Institutes of Health (U.S.)
Publisher: [Bethesda, Md. : National Institutes of Health, 2007]
Other Title(s): NIH neuroscience seminar series
Abstract: (CIT): Dr. Darnell will speak about how brain-specific splicing factors interacting with splicing silencer and enhancer elements lead to RNA isoforms in the brain that are different from the corresponding isoforms in other organs. One of these splicing factors, NOVA, has a predilection for regulating the splicing of RNAs that encode proteins acting at the neuronal synapse. Indeed, in the absence of NOVA in knock-out mice, synaptic NOVA targets are changed in sequence though not in level, with the consequence that LTP of slow inhibitory postsynaptic currents is completely and specifically absent. So, don't forget splicing when you think of gene expression! And by the way, because NOVA was discovered as a target of an auto-immune reaction in patients with a particular form of a paraneoplastic neurological syndrome, Dr. Darnell's talk should also be interesting to immunologists and clinicians. NIH Neuroscience Seminar Series.
Subjects: Brain--physiology
Protein Interaction Mapping
Protein Isoforms
RNA Splicing
Synapses--physiology
Publication Types: Government Publications
Lectures
Download: Download Video
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NLM Classification: WL 102.8
NLM ID: 101463227
CIT File ID: 14215
CIT Live ID: 6173
Permanent link: http://videocast.nih.gov/launch.asp?14215

 

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