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Sponsored by: |
National Cancer Institute (NCI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001702 |
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Blastomycosis dermatitidis. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of Blastomycosis dermatitidis infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive Blastomycosis dermatitidis infection.
Condition |
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Blastomycosis |
Study Type: | Observational |
Official Title: | Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection |
Estimated Enrollment: | 400 |
Study Start Date: | July 1998 |
Estimated Study Completion Date: | June 2006 |
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Blastomycosis Dermatitidis. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor Ila and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of Blastomycosis Dermatitidis infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive Blastomycosis Dermatitidis infection.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients in the database have been confirmed with a diagnosis of Blastomycosis dermatitides infection by a combination of isolation of the yeast form in a diagnostic microbiology laboratory and/or an elevated cryptococcal antigen titer (which is commercially available).
Only patients diagnosed and treated in the United States and Canada will be included in this analysis.
Only patients who are not co-infected with HIV will be included in the study.
Patient samples will be collected and clinical data will be evaluated only after signed consent has been obtained.
Contact: NCI Referral Office | ncissc@mail.nih.gov | |
Contact: CSSC | 8886241937 | ncicssc@mail.nih.gov |
United States, Maryland | |
National Cancer Institute (NCI) | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 980138, 98-C-0138 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001702 |
Health Authority: | United States: Federal Government |
Genetic Variant Alleles Risk Factor Cancer Transplantation |
Mycoses Skin Diseases, Infectious Skin Diseases HIV Infections |
Blastomycosis Acquired Immunodeficiency Syndrome Dermatomycoses |
Infection |