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Sponsored by: |
National Cancer Institute (NCI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001336 |
Peripheral blood mononuclear cells (PBMC) will be collected from patients who have leukemia or lymphoma or other medical conditions involving altered lymphohematopoietic stem cell or immunological function. These PBMC will be assessed for cellular markers by flow cytometry and will be studied for in vitro T helper, effector and suppressor cell functions, to determine whether cell mediated immunity is involved in the condition, or indicative of therapeutic efficacy or is predictive for outcome. Peripheral blood stem cells (PBSC) from untreated donors and from cytokine treated donors will be assessed for cellular markers and in vitro growth characteristics that might be useful for identifying normal stem cell populations.
Condition |
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Immunologic Deficiency Syndrome Leukemia Lymphoma Neoplasm |
Study Type: | Observational |
Official Title: | In Vitro Studies of Immunological and Stem Cell Function in Peripheral Blood Mononuclear Cells in Patients |
Estimated Enrollment: | 1000 |
Study Start Date: | April 1993 |
Estimated Study Completion Date: | February 2003 |
Peripheral blood mononuclear cells (PBMC) and mobilized peripheral blood stem cells (PBSC) will be collected from patients who have leukemia or lymphoma or other medical conditions involving altered lymphohematopoietic stem cell or immunological function. These PBMC will be assessed for cellular markers by flow cytometry and will be studied for in vitro T helper, effector and suppressor cell functions, to determine whether cell mediated immunity is involved in the condition, or indicative of therapeutic efficacy or is predictive for outcome. PBSC will be assessed for cellular markers and in vitro growth characteristics that might be useful for identifying normal stem cell populations. Furthermore the capacity of stem cells to reconstitute the T lymphocyte lineage will be assessed using ex vivo explant cultures established with thymic or secondary lymphoid tissues.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients obtained from collaborators within and outside the NCI.
Study ID Numbers: | 930129, 93-C-0129 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001336 |
Health Authority: | United States: Federal Government |
Transplantation Cancer Cellular Immunity Stem Cell Function Immunodeficiency |
Lymphatic Diseases Leukemia Immunoproliferative Disorders |
Lymphoproliferative Disorders Lymphoma Immunologic Deficiency Syndromes |
Neoplasms Pathologic Processes Disease |
Neoplasms by Histologic Type Immune System Diseases Syndrome |