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Quitting Marijuana Use: Self-Report Study of Quitting Strategies and Withdrawal Symptoms
This study is currently recruiting participants.
Verified by University of Maryland, May 2008
Sponsors and Collaborators: University of Maryland
National Institute on Drug Abuse (NIDA)
Information provided by: University of Maryland
ClinicalTrials.gov Identifier: NCT00679016
  Purpose

This study will employ two self-report questionnaires to collect information from non-treatment seeking adults with a marijuana use history who have made at least one attempt to quit marijuana. The questionnaires will collect information about the socio-demographic characteristics, history of marijuana use, most difficult marijuana quit experience, and marijuana craving from study participants. The questionnaire seeks to identify strategies used to help with marijuana quitting among non-treatment seeking adult marijuana users, and identify withdrawal symptoms experienced during marijuana quitting and their relationship to the quitting strategies used and the outcome of the quit attempt. Data will be analyzed for patterns and correlations among the characteristics of the quit attempt, including any withdrawal symptoms, quitting strategies used, and its success. The marijuana craving data will be analyzed to evaluate the validity of this measure of marijuana craving.


Condition Intervention
Cannabis Withdrawal and Craving
Behavioral: Marijuana Quit Questionnaire
Behavioral: Marijuana Craving Questionnaire
Behavioral: Additional Questions about Marijuana Craving

MedlinePlus related topics: Marijuana
Drug Information available for: Cannabis GW-1000
U.S. FDA Resources
Study Type: Observational
Study Design: Cross-Sectional
Official Title: Quitting Marijuana Use: Self-Report Study of Quitting Strategies and Withdrawal Symptoms

Further study details as provided by University of Maryland:

Primary Outcome Measures:
  • Marijuana Quit Questionnaire, Marijuana Craving Questionnaire, and Additional Questions about Marijuana Craving [ Time Frame: 1 to 2 hours ] [ Designated as safety issue: No ]

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 1200
Study Start Date: November 2006
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Individuals with a history of marijuana use who have made at least one attempt to quit marijuana use.
Behavioral: Marijuana Quit Questionnaire
The Marijuana Quit Questionnaire collects information on 3 domains: socio-demographic characteristics, history of marijuana use (including any associated problems), and characteristics of subjects hardest (self-defined) quit attempt (including reasons for quitting, coping strategies to help quit, withdrawal symptoms, and substance use before and during the quit attempt.
Behavioral: Marijuana Craving Questionnaire
The Marijuana Craving Questionnaire collects information about the subjective experience of craving for marijuana.
Behavioral: Additional Questions about Marijuana Craving
The Additional Questions about Marijuana Craving collects information about the subjective experience of craving for marijuana.

Detailed Description:

After giving informed consent, subjects will complete three sets of questions: Marijuana Quit Questionnaire (Appendix A), Marijuana Craving Questionnaire-12-item version (Appendix B), and 8 additional questions about marijuana craving (Appendix C). These questionnaires should take about 1-2 hours to complete. A staff member will be available to assist the subject as needed, e.g. to answer any questions from the subject and to collect the completed questionnaires. Subjects will not take the questionnaires if they are unable to cooperate or give apparently valid answers because of agitation, acute psychosis, or other psychological states. The subject may request to take a break or stop the session at any time. If a subject is not will or able to complete the questionnaires in one session, the staff member will arrange additional sessions until all questionnaires have been completed. After completion of the questionnaires (or is becomes clear that the subject is unable or unwilling to complete all questionnaires), the subject will be discharged from the study. Data will also be collected from up to 200 additional adult subjects participating in two IRB-approved outpatient marijuana studies conducted by Dr. Aimee McRae at the Medical University of South Carolina, Charleston, SC. These data will be sent to NIDA identified only by a subject ID number. NIDA investigators have no contact with these subjects, do not know the code linking ID number with subjects identity, and do not receive any personally identifiable information. Data from paper questionnaires will be entered into electronic (computer) format for later analysis. If warranted, a computer-administered version of the questionnaire may be developed. The Marijuana Quit Questionnaire (Appendix A) collects information on 3 domains: sociodemographic characteristics, history of marijuana use (including any associated problems), and characteristics of subjects hardest (self-defined) quit attempt (including reasons for quitting, coping strategies to help quit, withdrawal symptoms, and substance use before and during the quit attempt). Questions related to marijuana-associated problems were adapted from the Cannabis Use Disorders Identification Test (CUDIT) (Adamson and Sellman 2003) and the diagnostic criteria for cannabis abuse and dependence in DSM-IV (American Psychiatric Association 2000). Questions about reasons for quitting were drawn from published questionnaires used to study motivation for quitting among treatment-seeking marijuana users (Helmus, Downey, Wang, Rhodes, and Schuster 2001;McBride, Curry, Stephens, Wells, Roffman, and Hawkins 1994;Stephens, Wertz, and Roffman 1993), supplemented with questions from published questionnaires used to study motivation for tobacco smoking cessation (Selden, Clark, and Curry 1990). Questions related to coping strategies were adapted from studies of spontaneous quitters from alcohol and other drugs (Walters 2000;Sobell, Ellingstad, and Sobell 2000). Questions about marijuana withdrawal symptoms were drawn from published studies of marijuana withdrawal (Budney, Moore, Vandrey, and Hughes 2003;Smith 2002). Questions dealing with aggression during marijuana withdrawal were adapted from the Conflict Tactics Scale, a validated self-report measure of aggressive behavior (Straus et al., 1996). Questions about substance use before and during quit attempts were based on the Drug Use Frequency self-report measure (O'Farrell, Fals-Stewart, and Murphy 2003). The 12-item Marijuana Craving Questionnaire (MCQ-12; Appendix B) was derived from a larger 47-item Marijuana Craving Questionnaire (MCQ-47). Factor analysis of the MCQ-47 yielded four factors: compulsivity, emotionality, expectancy, and purposefulness (Heishman, Singleton, and Liguori 2001). The MCQ-12 was constructed by selecting the three items from each factor that exhibited optimal within-factor reliability (Cronbach¿s alpha coefficient) and inter-item correlation. All items are scored on a 1 to 7 scale (Strongly Disagree = 1 to Strongly Agree = 7). The scores of the three items in each factor are summed to generate a total factor score (range 3 to 21). Eight additional questions about marijuana craving (Appendix C) will be used to validate the MCQ-12.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Non-treatment seeking adults with a history of marijuana use and at least on past attempt to quit marijuana use.

Criteria

Inclusion Criteria:

  • Age 18 or older
  • Have made at least one attempt to quit marijuana use
  • Able to give valid informed consent
  • Reading level at least 6th grade, based on WRAT which is administered during recruitment
  • Ability to read English (because there is no non-English version of the questionnaires)

Exclusion Criteria:

  • Under age 18
  • Never using marijuana
  • No history of marijuana quit attempt
  • Inability to give informed consent
  • Reading level below 6th grade, based on WRAT
  • Inability to read English
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00679016

Contacts
Contact: Deanna Kelly, PharmD, BCPP 410-402-6860 dkelly@mprc.umaryland.edu
Contact: Jared A Linthicum, M.S. 410-402-6416 jlinthic@mprc.umaryland.edu

Locations
United States, Maryland
National Institute on Drug Abuse, Intramural Research Program Completed
Baltimore, Maryland, United States, 21224
Maryland Psychiatric Research Center, University of Maryland School of Medicine Recruiting
Baltimore, Maryland, United States, 21228
Contact: Deanna Kelly, PharmD, BCPP     410-402-6860     dkelly@mprc.umaryland.edu    
Contact: Jared A Linthicum, M.S.     410-402-6416     jlinthic@mprc.umaryland.edu    
Principal Investigator: Deanna Kelly, PharmD, BCPP            
Sponsors and Collaborators
University of Maryland
Investigators
Principal Investigator: Deanna Kelly, PharmD, BCPP Maryland Psychiatric Research Center, University of Maryland School of Medicine
  More Information

Responsible Party: Maryland Psychiatric Research Center, University of Maryland School of Medicine ( Deanna Kelly, PharmD, BCPP, Associate Professor of Psychiatry at University of Maryland School of Medicine and Chief of the Inpatient Research Program at the Maryland Psychiatric Research Center )
Study ID Numbers: H-28065, 408
Study First Received: May 12, 2008
Last Updated: May 15, 2008
ClinicalTrials.gov Identifier: NCT00679016  
Health Authority: United States: Institutional Review Board

Keywords provided by University of Maryland:
Cannabis
Marijuana
Withdrawal
Craving
Questionnaire
Quitting

Study placed in the following topic categories:
Smoking
Substance Withdrawal Syndrome
Mental Disorders
Substance-Related Disorders
Disorders of Environmental Origin
Marijuana Smoking
Marijuana Abuse

Additional relevant MeSH terms:
Habits

ClinicalTrials.gov processed this record on January 15, 2009