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Sponsored by: |
Holstebro Hospital |
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Information provided by: | Holstebro Hospital |
ClinicalTrials.gov Identifier: | NCT00678184 |
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake.
Condition | Intervention | Phase |
---|---|---|
Healthy Subjects |
Drug: Atorvastatin |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Pharmacokinetics/Dynamics Study |
Official Title: | The Effect of Acute HMG-CoA-Reductase Inhibition (Atorvastatin) on Renal Sodium Excretion, Renal Hemodynamics, Tubular Function and Vasoactive Hormones in Healthy Subjects During Normal and High Sodium Intake |
Enrollment: | 23 |
Study Start Date: | January 2007 |
Study Completion Date: | October 2007 |
Primary Completion Date: | October 2007 (Final data collection date for primary outcome measure) |
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake.
We wanted to analyze if changes in renal hemodynamics, tubular function, hormones, blood pressure and HR under acute treatment with atorvastatin depends on sodium intake.
Ages Eligible for Study: | 20 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Denmark | |
Department of Medical Research, Holstebro Hospital | |
Holstebro, Denmark, 7500 | |
Medical Research | |
Holstebro, Denmark, 7500 |
Principal Investigator: | Erling B. Pedersen, Professor | Dept. of medical reaserch, Holstebro Hospital, Denmark |
Study ID Numbers: | MED.RES.HOS.2006.03.LP |
Study First Received: | May 13, 2008 |
Last Updated: | May 14, 2008 |
ClinicalTrials.gov Identifier: | NCT00678184 |
Health Authority: | Denmark: Danish Medicines Agency |
Atorvastatin healthy sodium excretion hemodynamics tubular function |
Healthy Atorvastatin |
Antimetabolites Molecular Mechanisms of Pharmacological Action Therapeutic Uses Antilipemic Agents |
Enzyme Inhibitors Anticholesteremic Agents Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharmacologic Actions |