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Sponsored by: |
HaEmek Medical Center, Israel |
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Information provided by: | HaEmek Medical Center, Israel |
ClinicalTrials.gov Identifier: | NCT00678028 |
Due to genetic polymorphism about 15%-30% of the world population have low levels of MBL (Mannose Binding Lectin) in serum (below 500ng/mL). Different studies reported correlation between polymorphism in the MBL gene with low levels of MBL in serum and higher frequency of recurrent infections, severity of sepsis, ARDS and other infections. Urinary Tract Infection (UTI) is one of the very common infection in women. Since MBL is part of the innate immunity and there are proofs of relation between patients with recurrent infections and lack of MBL, we decided to explore a possible relation between low levels of MBL and different genotypes of MBL in young women and the risk to develop recurrent UTI.
Condition |
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Recurrent Urinary Tract Infections |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection |
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
young women with recurrent UTI - study group and young women witout recurrent UTI - a control group
Inclusion Criteria:
Exclusion Criteria:
Contact: Orna Nitzan, MD | 972-4-6495132 | orna_ni@clalit.org.il |
Contact: Raul Raz, M.D. | 972-4-6494259 | raz_r@clalit.org.il |
Israel | |
Ha'Emek Medical Center | Recruiting |
Afula, Israel, 18101 | |
Contact: Orna Nitzan, MD 972-4-6495132 orna_ni@clalit.org.il | |
Contact: Raul Raz, M.D. 972-4-6494259 raz_r@clalit.org.il | |
Principal Investigator: Orna Nitzan, MD | |
Sub-Investigator: Raul Raz, MD | |
Sub-Investigator: Bibiana Chazan, MD | |
Sub-Investigator: Yasir Hujeirat, PhD | |
Sub-Investigator: Raul Colodner, PhD |
Responsible Party: | Ha'emek Medical Center, Afula, Israel ( Dr. Orna Nitzan ) |
Study ID Numbers: | 0080-07-EMC |
Study First Received: | February 17, 2008 |
Last Updated: | May 14, 2008 |
ClinicalTrials.gov Identifier: | NCT00678028 |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
MBL, UTI |
Urologic Diseases Urinary Tract Infections Recurrence |
Communicable Diseases Infection |