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Sponsored by: |
Wake Forest University |
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Information provided by: | Wake Forest University |
ClinicalTrials.gov Identifier: | NCT00697034 |
The purpose of this research study is to examine the role of nerves in the skin in psoriasis and to better understand the effects of capsaicin in psoriasis.In this study, capsaicin will be compared to a moisturizer (aquaphor ointment).
Condition | Intervention | Phase |
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Psoriasis |
Drug: Capsaicin |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Open Label, Single Group Assignment, Efficacy Study |
Official Title: | Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin |
Enrollment: | 12 |
Study Start Date: | June 2006 |
Estimated Study Completion Date: | October 2008 |
Primary Completion Date: | August 2007 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
Study subjects will be patients with chronic plaque-type psoriasis
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Drug: Capsaicin
natural alkaloid derived from hot chili peppers and activates vanilloid receptors that are also activated by endogenous cannabinoid anandamide applied three times daily
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, North Carolina | |
Wake Forest University Health Sciences Dermatology | |
Winston Salem, North Carolina, United States, 27157 |
Principal Investigator: | Gil Yosipovitch, MD | Wake Forest University |
Responsible Party: | Wake Forest University Health Sciences ( Gil Yosipovitch, MD ) |
Study ID Numbers: | 05-467 |
Study First Received: | June 9, 2008 |
Last Updated: | June 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00697034 |
Health Authority: | United States: Institutional Review Board |
Skin Diseases Psoriasis Capsaicin Skin Diseases, Papulosquamous |
Sensory System Agents Therapeutic Uses Physiological Effects of Drugs Antipruritics |
Peripheral Nervous System Agents Dermatologic Agents Pharmacologic Actions |