Full Text View  
  Tabular View  
  Contacts and Locations  
  No Study Results Posted  
  Related Studies  
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
This study is not yet open for participant recruitment.
Verified by Hospital Centre Biel/Bienne, June 2008
Sponsors and Collaborators: Hospital Centre Biel/Bienne
Brahms AG
Information provided by: Hospital Centre Biel/Bienne
ClinicalTrials.gov Identifier: NCT00696605
  Purpose

The are 2 principal goals in this study:

  1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states.
  2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

Condition
Hypoosmolality
Hyperosmolality
Renal Failure

MedlinePlus related topics: Drinking Water Kidney Failure
Drug Information available for: Sodium chloride Argipressin Vasopressins
U.S. FDA Resources
Study Type: Observational
Study Design: Prospective
Official Title: Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Further study details as provided by Hospital Centre Biel/Bienne:

Estimated Enrollment: 35
Study Start Date: July 2008
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy volunteers; patients with chronic renal failure

Criteria

Inclusion Criteria:

  • chronic renal failure grade I through IV
  • healthy age-matched controls

Exclusion Criteria:

  • chronic renal failure grade V
  • heart failure
  • liver disease
  • nephrotic syndrome
  • anemia (hemoglobin level < 100 g/L)
  • uncontrolled hypertension (systolic BP > 160 mmHg; diastolic BP > 95 mm Hg)
  • coexisting severe disease
  • known thyroid disease
  • known hypocortisolism
  • known hypercortisolism
  • known diabetes insipidus
  • pregnancy
  • lactation
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: Medical Clinic, Hospital Center Biel/Bienne, Switzerland ( Dr. Jonas Rutishauser )
Study ID Numbers: Swiss AVP-Copeptin Trial
Study First Received: June 10, 2008
Last Updated: June 11, 2008
ClinicalTrials.gov Identifier: NCT00696605  
Health Authority: Switzerland: Ethikkommission

Keywords provided by Hospital Centre Biel/Bienne:
Hypoosmolality
Hyperosmolality
Copeptin
Vasopressin

Study placed in the following topic categories:
Arginine Vasopressin
Renal Insufficiency
Urologic Diseases
Vasopressins
 Healthy
Kidney Diseases
Kidney Failure

ClinicalTrials.gov processed this record on January 15, 2009



U.S. National Library of Medicine,  Contact Help Desk
U.S. National Institutes of Health,  U.S. Department of Health & Human Services,
USA.gov,  Copyright,  Privacy,  Accessibility,  Freedom of Information Act

U.S. National Institutes of Health U.S. National Library of Medicine U.S. Department of Health & Human Services