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Impact of General Anaesthetics on Excitability of the Peripheral Sensory Nerve
This study is currently recruiting participants.
Verified by University of Zurich, March 2008
Sponsored by: University of Zurich
Information provided by: University of Zurich
ClinicalTrials.gov Identifier: NCT00696254
  Purpose

The aim of this study is to investigate the effect of general anaesthetics on nerve excitability. We use the method of threshold tracking to measure selected parameters of nerve excitability.


Condition Intervention Phase
General Anesthesia
 Behavioral: Threshold tracking
 Phase I

MedlinePlus related topics: Anesthesia
U.S. FDA Resources
Study Type: Observational
Study Design: Case Control, Prospective
Official Title: Impact of General Anaesthetics on Excitability of the Peripheral Sensory Nerve

Further study details as provided by University of Zurich:

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 40
Study Start Date: March 2008
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: Threshold tracking
    Nerve excitability measurement
Detailed Description:

The median nerve of the patients will be stimulated electrically before, during and after the therapy. A computerized threshold-tracking protocol will be used to measure strength-duration time constants (τSD), threshold electrotonus to 100-ms polarizing currents (to measure accommodation) and the recovery cycle of excitability following a conditioning nerve impulse (refractoriness, superexcitability and late subexcitability). The measurements will be made before and after induction of anesthesia.

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

German speaking patients scheduled for surgery under general anaesthesia.

Criteria

Inclusion criteria:

  1. German speaking patients scheduled for surgery under general anaesthesia.
  2. Weight 50 - 100 kg
  3. Signed informed consent

Exclusion criteria:

  1. known peripheral neuropathy
  2. Diabetes mellitus
  3. Neuro-psychiatric Diagnosis
  4. pregnant/ breast-feeding women
  5. congestive heart disease
  6. more than 2 risk factors (out of 4) for PONV (female, non-smoker, known PONV, opioids postoperatively)
  7. participants of other studies
  8. inability of verbal expression
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00696254

Contacts
Contact: Konrad Maurer, MD +41 (0)44 255 11 11 konrad.maurer@usz.ch
Contact: Donat R Spahn, MD donat.spahn@usz.ch

Locations
Switzerland
University Hospital Zurich Recruiting
Zurich, Switzerland
Contact: Konrad Maurer, Dr.         konrad.maurer@usz.ch    
Contact: Donat R Spahn, Prof.         donat.spahn@usz.ch    
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Konrad Maurer, MD University of Zurich
  More Information

Responsible Party: University Hospital Zurich ( Konrad Maurer )
Study ID Numbers: 5-2008
Study First Received: March 17, 2008
Last Updated: June 11, 2008
ClinicalTrials.gov Identifier: NCT00696254  
Health Authority: Switzerland: Swissmedic

ClinicalTrials.gov processed this record on January 15, 2009



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