Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
University of California, Irvine Beckman Laser Institute University of California Irvine Renal Clinic, University of California, Irvine |
---|---|
Information provided by: | University of California, Irvine |
ClinicalTrials.gov Identifier: | NCT00793806 |
The Diffuse Optical Spectroscopy (DOS) measure the absolute concentrations of reduced and oxygenated hemoglobins ([Hb-R] and [HbO2], respectively) as well as the water and lipid concentrations of the tissue.
Condition | Intervention |
---|---|
Chronic Kidney Disease |
Device: Diffuse Optical Spectroscopy |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Non-Invasive Spectroscopic Measurements of the Concentrations of Blood, Water, and Lipids in Tissues |
Estimated Enrollment: | 100 |
Study Start Date: | March 2008 |
Estimated Study Completion Date: | June 2013 |
Estimated Primary Completion Date: | June 2013 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
---|---|
chronic kidney disease
chronic kidney disease
|
Device: Diffuse Optical Spectroscopy
near-infrared (NIR)
|
DOS have been shown to correlate with invasive measures of cardiac output, mean arterial pressure, blood loss, and blood hemoglobin concentration.
The researchers want to use DOS as a means to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study.
The researchers want compared to a variety of laboratory parameters routinely measured in CKD subjects (GFR, proteinuria, Hg, serum albumin, bicarbonate, calcium, phosphorous, iron saturation, ferritin, lipid profiles, PTH) and to clinical parameters such as cause of CKD, blood pressure and dialysis-related parameters.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
primary care clinic
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
University of California Medical Center: Dialysis Unit | |
Orange, California, United States, 92868 |
Principal Investigator: | Madeleine Pahl, M.D. | Renal Clinic, University of California, Irvine |
Responsible Party: | Renal Clinic, University of California, Irvine ( Madeleine V. Pahl, M.DAssociate Professor of Medicine and Director of the Renal Clinic at UCI. ) |
Study ID Numbers: | LAMMP-30139-NIH |
Study First Received: | November 14, 2008 |
Last Updated: | November 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00793806 |
Health Authority: | United States: Institutional Review Board |
chronic kidney disease |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic Kidney Failure, Chronic Stress |
Kidney Diseases Congenital Abnormalities Kidney Failure Inflammation |