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Sponsored by: |
National Human Genome Research Institute (NHGRI) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00046059 |
Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest that there is a genetic component to ADHD. Scientists believe that it is a complex disorder in which two or more genes may be involved.
Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child.
Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.
Condition |
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Attention Deficit Disorder With Hyperactivity |
Study Type: | Observational |
Official Title: | Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD) |
Estimated Enrollment: | 4000 |
Study Start Date: | February 2000 |
A study of the hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder has been undertaken using a two armed approach: 1) a large, extended pedigree study done in Columbia, South America in a population isolate called the Paisa; and 2) a U.S. based study with at least one affected child and at least one sibling (either affected or unaffected), and their parents. Following careful phenotyping, DNA from blood samples from these two groups will be analyzed through a genome-wide scan for linkage and positional candidate approach to search for genes associated with ADHD. The prefrontal cortex is known to play a very important role in the processing of emotions and impulsivity. Measurement of brain metabolites in this region may be very useful in phenotyping ADHD. Thus, in the Columbian population, in a subset of already recruited individuals, phenotyping will include proton magnetic resonance spectroscopy (H MRS) to detect biochemical phenotypes which may be correlated with genetic markers for ADHD.
Ages Eligible for Study: | 7 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
For both the U.S. and the Columbian Studies, we plan to obtain blood samples from subjects meeting the following criteria:
Children , ages 7-17, affected with ADHD with siblings who are either affected or unaffected, and their parents. (in the Columbian Study, we will also gather information and blood samples from extended families).
Adult participants 18 years or older selected for MRS from the Paisa population will be included if they:
do not have a mental condition such as claustrophobia which would make magnetic resonance tehcnology unacceptable to them.
EXCLUSION CRITERIA:
Exclude the following (if the condition could cause false positive ADHD):
No bilineal families for statistical reasons are to be included, i.e. families in which both father and mother are known to be affected with ADHD. In order to involve either parent, there must be affected siblings.
Include, but note:
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, California | |
University of California, Irvine Medical Center | Recruiting |
Orange, California, United States, 92668 | |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
Colombia | |
University of Antioquia | Recruiting |
Medillin, Colombia |
Study ID Numbers: | 000058, 00-HG-0058 |
Study First Received: | September 18, 2002 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00046059 |
Health Authority: | United States: Federal Government |
Linkage Gene Identification ADHD Hyperactivity |
Attention Deficit Hyperactivity Disorder ADHD Hyperactivity |
Signs and Symptoms Attention Deficit Disorder with Hyperactivity Mental Disorders Mental Disorders Diagnosed in Childhood |
Neurologic Manifestations Attention Deficit and Disruptive Behavior Disorders Hyperkinesis Dyskinesias |
Pathologic Processes Disease Nervous System Diseases |