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Sponsored by: |
Boston University |
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Information provided by: | Boston University |
ClinicalTrials.gov Identifier: | NCT00554203 |
Experimental studies suggest that systemic inflammation leads to endothelial dysfunction and atherosclerosis. This study will examine the effects of the anti-inflammatory drug sulfasalazine on endothelial function in patients with coronary artery disease. Subjects will be treated with sulfasalazine or to placebo for six weeks. After a two-week rest period, subjects will cross over to the alternative treatment. Endothelium-dependent flow-mediated dilation of the brachial artery will be studied before and after each drug. We hypothesize that anti-inflammatory therapy will reverse endothelial dysfunction in patients with coronary artery disease.
Condition | Intervention |
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Coronary Artery Disease |
Drug: Sulfasalazine |
Study Type: | Interventional |
Study Design: | Basic Science, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Crossover Assignment |
Official Title: | Effect of Sulfasalazine on Endothelial Function |
Estimated Enrollment: | 60 |
Study Start Date: | July 2003 |
Study Completion Date: | December 2007 |
Primary Completion Date: | December 2007 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |
Boston Medical Center | |
Boston, Massachusetts, United States, 02118 |
Principal Investigator: | Joseph A Vita, MD | Boston Medical Center |
Study ID Numbers: | H-22844 |
Study First Received: | November 5, 2007 |
Last Updated: | May 13, 2008 |
ClinicalTrials.gov Identifier: | NCT00554203 |
Health Authority: | United States: Institutional Review Board |
Arterial Occlusive Diseases Coronary Disease Heart Diseases Sulfasalazine Myocardial Ischemia |
Vascular Diseases Arteriosclerosis Ischemia Coronary Artery Disease |
Anti-Inflammatory Agents Anti-Infective Agents Physiological Effects of Drugs Gastrointestinal Agents Pharmacologic Actions Analgesics, Non-Narcotic Sensory System Agents |
Therapeutic Uses Cardiovascular Diseases Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |