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Sponsored by: |
Tehran University of Medical Sciences |
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Information provided by: | Tehran University of Medical Sciences |
ClinicalTrials.gov Identifier: | NCT00467948 |
Patients who need major head & neck surgery are at risk of post operative wound infection. In spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists in the optimal antibiotic regimen
Condition | Intervention | Phase |
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Laryngeal Cancer |
Drug: cefazolin |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Dose Comparison, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Double Blind Randomised Study of 2 Days and 5 Days Cefazolin Prophylactic Method in Laryngeal Oncologic Surgery |
Enrollment: | 90 |
Study Start Date: | June 2004 |
Study Completion Date: | March 2006 |
Patients undergoing laryngeal oncologic surgery are at relatively high risk of developing complication.
Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery was reviewed in many researches [6] but considering the costs and morbidities of prolonged antibiotic regimen we have presented a prospective and randomized study in 90 patients comparing the efficacy of 2 day over 5 day protocols.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:e.
Exclusion Criteria:
Iran, Islamic Republic of | |
Imam khomaini hospital | |
tehran, Iran, Islamic Republic of, 19799 |
Study Chair: | taghi khorsandi, professor | tehran university of medical science |
Study ID Numbers: | BS_200306 |
Study First Received: | April 29, 2007 |
Last Updated: | April 30, 2007 |
ClinicalTrials.gov Identifier: | NCT00467948 |
Health Authority: | Iran: Ethics Committee |
clean contaminated, laryngectomy, wound infection |
Cefazolin Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Respiratory Tract Diseases Head and Neck Neoplasms |
Laryngeal carcinoma Laryngeal Neoplasms Laryngeal Diseases Wound Infection |
Anti-Infective Agents Anti-Bacterial Agents Respiratory Tract Neoplasms Neoplasms |
Neoplasms by Site Therapeutic Uses Pharmacologic Actions |