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Sponsors and Collaborators: |
University of California, San Diego National Institute of Mental Health (NIMH) |
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Information provided by: | University of California, San Diego |
ClinicalTrials.gov Identifier: | NCT00703885 |
The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function.
Condition | Intervention | Phase |
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Anxiety Disorders |
Drug: alprazolam Drug: placebo |
Phase IV |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Single Blind (Subject), Crossover Assignment |
Official Title: | PharmacofMRI of Anxiolytic Medications (Alprazolam) |
Enrollment: | 16 |
Study Start Date: | January 2008 |
Study Completion Date: | August 2008 |
Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Active Comparator
Alprazolam 0.25 mg PO (liquid) will be administered 1 hour prior to fMRI scan
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Drug: alprazolam
alprazolam 0.25 mg PO (liquid) to be administered 1 hour prior to fMRI scan
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2: Active Comparator
Alprazolam 1 mg PO (liquid) will be administered 1 hour prior to fMRI scan
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Drug: alprazolam
Alprazolam 1 mg PO (liquid) will be administered 1 hour prior to fMRI scan
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Placebo: Placebo Comparator |
Drug: placebo
Placebo (liquid) to be administered 1 hour prior to fMRI scan
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Increased amygdala and insula activity have been implicated in neurobiological models of anxiety. Using fMRI, the anxiolytic medication, lorazepam, has previously been found to decrease activation in these areas during the processing of emotional stimuli. This study aims to replicate those results but by using a different medication, alprazolam. An eventual aim of this study, in combination with future studies, is to evaluate the utility of fMRI as a tool to identify anxiolytic function in both established and novel compounds that may be used to treat anxiety.
Ages Eligible for Study: | 18 Years to 30 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
University of California, San Diego | |
La Jolla, California, United States, 92037 |
Principal Investigator: | Murray B Stein, MD, MPH | University of California, San Diego |
Responsible Party: | University of California, San Diego ( Murray B. Stein ) |
Study ID Numbers: | UCSD IRB 060407 - A |
Study First Received: | June 20, 2008 |
Last Updated: | September 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00703885 |
Health Authority: | United States: Institutional Review Board |
functional magnetic resonance imaging fMRI alprazolam anxiety disorders |
Alprazolam Anxiety Disorders Mental Disorders |
Neurotransmitter Agents Tranquilizing Agents Molecular Mechanisms of Pharmacological Action GABA Modulators Physiological Effects of Drugs Psychotropic Drugs Central Nervous System Depressants |
Pharmacologic Actions Therapeutic Uses Hypnotics and Sedatives GABA Agents Anti-Anxiety Agents Central Nervous System Agents |