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Sponsored by: |
Catholic University of the Sacred Heart |
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Information provided by: | Catholic University of the Sacred Heart |
ClinicalTrials.gov Identifier: | NCT00702936 |
The purpose of this study is to compare the antinflammatory and endothelial progenitor cell (EPC) mobilizing effect of Ramipril and Telmisartan in patients presenting with acute coronary syndrome
Condition | Intervention | Phase |
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Acute Coronary Syndrome Myocardial Infarction Coronary Disease |
Drug: TELMISARTAN Drug: RAMIPRIL |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Uncontrolled, Parallel Assignment, Efficacy Study |
Official Title: | Telmisartan vs Ramipril for Reduction of Inflammation and Recruitment of Endothelial Progenitor Cells After Acute Coronary Syndrome |
Estimated Enrollment: | 50 |
Study Start Date: | November 2007 |
Estimated Study Completion Date: | November 2008 |
Estimated Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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R: Active Comparator
Twenty-five patients assigned to ramipril 5 mg daily
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Drug: RAMIPRIL
5 mg daily
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T: Active Comparator
Twenty-five patients assigned to Telmisartan 80 mg daily
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Drug: TELMISARTAN
80 mg daily
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Ages Eligible for Study: | 40 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Italo Porto, MD, PhD | 0039(0)6-30154127 | i.porto@doctors.org.uk |
Contact: Italo Porto, MD, PhD | italo.porto@gmail.com |
Italy | |
Catholic University of the Sacred Heart | Recruiting |
Rome, Italy, 00168 | |
Contact: Italo Porto, MD, PhD i.porto@doctors.org.uk | |
Contact: Luca Di Vito, MD divitoluca@yahoo.it | |
Principal Investigator: Italo Porto, MD, PhD | |
Sub-Investigator: Luca Di Vito, MD |
Principal Investigator: | Italo Porto, MD, PhD | Catholic University of the Sacred Heart |
Principal Investigator: | Luca Di Vito, MD | Catholic University of the Sacred Heart |
Responsible Party: | Catholic University of the Sacred Heart ( Catholic University of the Sacred Heart ) |
Study ID Numbers: | ILG-1 |
Study First Received: | June 19, 2008 |
Last Updated: | June 19, 2008 |
ClinicalTrials.gov Identifier: | NCT00702936 |
Health Authority: | Italy: National Monitoring Centre for Clinical Trials - Ministry of Health |
Arterial Occlusive Diseases Heart Diseases Myocardial Ischemia Vascular Diseases Ischemia Arteriosclerosis Angiotensin II Ramipril |
Inflammation Coronary Disease Necrosis Acute Coronary Syndrome Telmisartan Infarction Myocardial Infarction Coronary Artery Disease |
Disease Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions Protease Inhibitors |
Angiotensin II Type 1 Receptor Blockers Pathologic Processes Syndrome Therapeutic Uses Angiotensin-Converting Enzyme Inhibitors Cardiovascular Diseases |