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Sponsored by: |
Weill Medical College of Cornell University |
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Information provided by: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00405093 |
Primary Objective: The aim of this study is to assess the effects of Aprotinin (an antifibrinolytic drug used to reduce bleeding during cardiac surgery) on renal function in patients undergoing surgery with use of hypothermic bypass and circulatory arrest for repair of the thoracic aorta.
Secondary Objective: To compare the effects of Aprotinin and Amicar on major vascular outcomes following thoracic aorta surgery with use of hypothermic bypass and circulatory arrest.
Condition |
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Circulatory Arrest |
Study Type: | Observational |
Study Design: | Case-Only, Retrospective |
Official Title: | Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta. A Retrospective Study. |
Estimated Enrollment: | 1000 |
Study Start Date: | July 2006 |
Estimated Study Completion Date: | July 2008 |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Adult male and female patients having surgery of ascending and aortic arch with the use of Antifibrinolytic agents (Aprotinin and Aminocaproic Acid)
Inclusion Criteria:
Exclusion Criteria:
Contact: Manuel Fontes, MD | 212-746-0395 | maf2029@med.cornell.edu |
United States, New York | |
The New York Presbyterian Hospital - Weill Medical College of Cornell University | Recruiting |
New York, New York, United States, 10021 | |
Contact: Manuel Fontes, MD 212-746-0395 maf2029@med.cornell.edu | |
Principal Investigator: Manuel Fontes, MD |
Principal Investigator: | Manuel Fontes, MD | Associate Professor |
Responsible Party: | Weill Cornell Medical College ( Manuel Fontes, MD ) |
Study ID Numbers: | 0607008636 |
Study First Received: | November 28, 2006 |
Last Updated: | February 21, 2008 |
ClinicalTrials.gov Identifier: | NCT00405093 |
Health Authority: | United States: Institutional Review Board |
cardiopulmonary bypass circulatory arrest aprotinin thoracic aorta surgery |
Hypothermia Aprotinin |
Serine Proteinase Inhibitors Coagulants Molecular Mechanisms of Pharmacological Action Therapeutic Uses Hematologic Agents |
Trypsin Inhibitors Enzyme Inhibitors Hemostatics Pharmacologic Actions Protease Inhibitors |