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Sponsors and Collaborators: |
University of Pittsburgh National Institute of Mental Health (NIMH) |
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Information provided by: | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00603018 |
Several studies in the past suggest that individuals who have or had anorexia nervosa may have alterations in brain serotonin. Serotonin seems to play an important role in regulating anxiety, mood, and other symptoms found in anorexia nervosa. We will be using a technology called Positron Emission Tomography (PET), which is a method used to take pictures of the body, in this case, the brain. Study participants will undergo two baseline PET scans on the first day of the study. They will then be given a medication called fluoxetine (also know as Prozac) to take for 8 weeks. At the end of the 8th week, they will return for a third PET scan. By comparing the brain scans, before and after fluoxetine treatment, we can understand more about how treatment with fluoxetine affects the serotonin receptors in the brain. We will be comparing brain serotonin system in women who have recovered from anorexia with healthy control women who have never had an eating disorder in order to gain a better understanding of changes in the serotonin system associated with eating disorders. This study may help shed light on how to make fluoxetine a more effective treatment for anorexia nervosa.
Condition | Intervention |
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Anorexia Nervosa |
Drug: Fluoxetine |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Parallel Assignment |
Official Title: | PET Imaging of Dopaminergic Transmission and Serotonin Markers in Anorexia Nervosa |
Estimated Enrollment: | 120 |
Study Start Date: | June 2007 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1
Recovered anorexia
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Drug: Fluoxetine
8 weeks of fluoxetine(2.5mg,5mg,10mg,20mg,30mg,40mg,40mg,40mg)each week per day.
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Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Pennsylvania | |
University of Pittsburgh Medical Center | |
Pittsburgh, Pennsylvania, United States, 15213 |
Principal Investigator: | Walter Kaye, M.D. | UPMC |
Responsible Party: | University of Pittsburgh Medical Center ( Walter Kaye, MD ) |
Study ID Numbers: | PRO06110005 |
Study First Received: | October 16, 2007 |
Last Updated: | October 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00603018 |
Health Authority: | United States: Institutional Review Board |
eating disorders anorexia nervosa anorexia PET brain imaging |
serotonin fMRI Prozac fluoxetine |
Fluoxetine Signs and Symptoms Dopamine Signs and Symptoms, Digestive Mental Disorders |
Anorexia Anorexia Nervosa Serotonin Eating Disorders |
Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Serotonin Agents Molecular Mechanisms of Pharmacological Action Therapeutic Uses Physiological Effects of Drugs |
Psychotropic Drugs Antidepressive Agents, Second-Generation Central Nervous System Agents Serotonin Uptake Inhibitors Antidepressive Agents Pharmacologic Actions |