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Sponsored by: |
University of Pittsburgh |
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Information provided by: | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00449735 |
This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of E. coli. Additionally, the adequacy of empiric antibiotic therapy for E. coli bloodstream infections will be assessed. Finally, outcome will be recorded - this is all-cause mortality at 28 days from the time of the first positive blood culture. Hypothesis: Ciprofloxacin resistant strains are associated with admission from nursing home and with prior quinolone use.
Condition |
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Bacterial Infections |
Study Type: | Observational |
Study Design: | Cohort, Retrospective |
Official Title: | Quinolone Resistance in Bloodstream Isolates of Escherichia Coli |
Estimated Enrollment: | 500 |
Study Start Date: | March 2007 |
The following information will be collected: age, sex, occupation, hospital location at the time of positive culture (ER, medical ward, ICU etc), date of positive culture, prior hospitalization, receipt of outpatient dialysis, home care or other regular medical care (eg, outpatient chemotherapy), presence of invasive devices, receipt of antibiotics, including their type and whether they were adequate for the resistance profile of the organism, prior positive microbiologic cultures, time and location of positive cultures, underlying diseases and severity of illness, presence of urinary or intravascular devices, recent immunomodulative therapies or radiation therapy, physical exam findings, laboratory and radiographical data, antimicrobial usage within 30 days of onset of the infection, microbiological data and resistance patterns, choice of antibiotics once organism identified, bacteriological outcomes, laboratory results, demographic information, medications, clinical outcome,gender, height, weight, ethnicity, and past medical history. We will collect information retrospectively.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
E coli positive cultures
Inclusion Criteria:
Clinical information is collected by chart review of "case" and "control" patients.
A "case A" patient is defined as follows:
A "case B" patient is defined as follows:
Exclusion Criteria:
Contact: David L Paterson, MD | 412-648-6401 | patersond@dom.pitt.edu |
Contact: Diana Lynn Pakstis, RN, BSN | 412-648-6553 | pakstisdl@dom.pitt.edu |
United States, Pennsylvania | |
University of Pittsburgh Medical Center | Recruiting |
Pittsburgh, Pennsylvania, United States, 15213 | |
Contact: David L Paterson, MD 412-648-6401 patersond@dom.pitt.edu | |
Contact: Diana Lynn Pakstis, RN, BSN 412-648-6553 pakstisdl@dom.pitt.edu | |
Sub-Investigator: Yohei Doi, MD | |
Principal Investigator: David L Paterson, MD |
Principal Investigator: | David L Paterson, MD | University of Pittsburgh |
Responsible Party: | UPMC ( David Paterson, MD ) |
Study ID Numbers: | PRO07030003 |
Study First Received: | March 19, 2007 |
Last Updated: | October 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00449735 |
Health Authority: | United States: Institutional Review Board |
positive isolates ecoli blood cultures positive cultures for ecoli blood stream infections |
Bacterial Infections |
Infection |