Treatment of Subclinical Hyperthyroidism - Full Text View

Sponsored by:	University Hospital, Strasbourg, France
Information provided by:	University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:	NCT00213720

Purpose

Objective: To determine if the treatment of subclinical hyperthyroidism will reduce the rate of atrial fibrillation, the main complication of this condition.

Condition	Phase
Subclinical Hyperthyroidism Atrial Fibrillation	Phase IV

Genetics Home Reference related topics: Brugada syndrome familial atrial fibrillation short QT syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Place de l'Iode RadioActif Dans l'HyperThyroïdiE Sub-Clinique (PIRHATES)/ Evaluation of the Interest of Subclinical Hyperthyroidism Treatment

Further study details as provided by University Hospital, Strasbourg, France:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

serum

Estimated Enrollment:	300
Study Start Date:	August 2005

Detailed Description:

Randomized open-labelled multicentre study comparing radioiodine vs medical supervision without treatment

Eligibility

Ages Eligible for Study:	50 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

patients referred to tertiary hospitals for advice on thyroïd disease

Criteria

Inclusion Criteria:

Men and women aged 50 and greater
Isolated decreased thyroid-stimulating hormone (TSH) with normal FT4 and FT3 levels

Exclusion Criteria:

Iodide overload
Non sinusal heart rhythm
Severe heart disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00213720

Contacts

Contact: Bernard Goichot, MD

333 88 12 75 93

bernard.goichot@chru-strasbourg.fr

Locations

France
Hopitaux Universitaires de Strasbourg	Recruiting
Strasbourg, France
Contact: Bernard Goichot, MD 333 88 12 75 93 bernard.goichot@chru-strasbourg.fr
Sub-Investigator: Jean-Louis Schlienger, MD
Sub-Investigator: Fabienne Grunenberger, MD
Sub-Investigator: Alain Pradignac, MD
Sub-Investigator: Stephane Vinzio, MD
Jacques Bringer	Not yet recruiting
Montpellier, France
Contact: Jacques Bringer 334 67 33 83 82 j-bringer@chu-montpellier.fr
Jean-Marcel Brun	Not yet recruiting
Dijon, France
Contact: Jean-Marcel Brun 333 80 29 34 53 jean-marcel.brun@chu-dijon.fr
Philippe Caron	Recruiting
Toulouse, France
Contact: Philippe Caron
Bernard Conte-Delvox	Not yet recruiting
Marseille, France
Contact: Bernard Conte-Delvox, MD 334 91 38 65 97 bernard.conte-delvox@ap-hm.fr
Brigitte Delemer	Recruiting
Reims, France
Contact: Brigitte Delemer, MD 333 26 78 75 33 / 79 42 brigitte.delemer@wanadoo.fr
Bruno Estour	Recruiting
Saint-Etienne, France
Contact: Bruno Estour, MD 334 77 12 77 27 bruno.estour@chu-st-etienne.fr
Sub-Investigator: Luc Millot, MD
Marc Klein	Recruiting
Nancy, France
Contact: Marc Klein 333 83 15 34 31 m.klein@chu-nancy.fr
Jean-Marc Kuhn	Recruiting
Rouen, France
Contact: Jean-Marc Kuhn, MD 332 32 88 90 82 jean-marc.kuhn@chu-rouen.fr
Pierre Lecomte	Recruiting
Tours, France
Contact: Pierre Lecomte, MD 332 47 47 87.03 lecomte@med.univ-tours.fr
Laurence Leenhardt	Not yet recruiting
Paris, France
Contact: Laurence Leenhardt, MD 331 42 17 62 81 laurence.leenhardt@psl.ap-hop-paris.fr
Centre Paul Strauss	Recruiting
Strasbourg, France, 67000
Contact: Olivier Schneegans, MD 0033388252428 oschneegans@strasbourg.fnclcc.fr
Principal Investigator: Olivier Schneegans, MD
Didier Maugendre	Not yet recruiting
Rennes, France
Contact: Didier Maugendre, MD 332 99 26 71 42 didier.maugendre@chu-rennes.fr
Jacques Orgiazzi	Recruiting
Lyon, France
Contact: Jacques Orgiazzi, MD 334 78 86 14 88 jacques.orgiazzi@chu-lyon.fr
Michel Rodier	Recruiting
Nimes, France
Contact: Michel Rodier, MD 334 66 68 33 21 michel.rodier@chu-nimes.fr
Patrick Roger	Not yet recruiting
Bordeaux, France
Contact: Patrick Roger, MD 335 57 65 64 33 patrick.roger@chu-bordeaux.fr
Claire Schvartz	Recruiting
Reims, France
Contact: Claire Schvartz, MD 333 26 50 43 21 claire.schvartz@reims.fnclcc.fr
Sub-Investigator: Béatrice Maes, MD
Sub-Investigator: Jean-Marie Pochart, MD
Marie-Pierre Teissier	Recruiting
Limoges, France
Contact: Marie-Pierre Teissier, MD 335 55 05 68 51 marie-pierre.teissier@chu-limoges.fr
Philippe Thiéblot	Not yet recruiting
Clermont-Ferrand, France
Contact: Philippe Thiéblot, MD 334 73 75 15 33 pthieblot@chu-clermontferrand.fr
Jean-Louis Wemeau	Recruiting
Lille, France
Contact: Jean-Louis Wemeau, MD 333 20 44 41 18 jl-wemeau@chru-lille.fr
CH de Montbrison	Not yet recruiting
Montbrison, France, 42605
Contact: Luc Millot, MD 0033477967853 l.millot@ch-montbrison.fr
Principal Investigator: Luc Millot, MD
Richard Marechaud	Recruiting
Poitiers, France
Contact: Richard Marechaud 335 49 44 43 80 r.marechaud@chu-poitiers.fr

Sponsors and Collaborators

University Hospital, Strasbourg, France

Investigators

Principal Investigator:

Bernard Goichot, MD

Hopitaux Universitaires de Strasbourg

More Information

Responsible Party:	Hôpitaux universitaires de Strasbourg, France ( Emmanuel LAVOUE, Directeur Adjoint de la DRCI )
Study ID Numbers:	3463
Study First Received:	September 13, 2005
Last Updated:	November 12, 2008
ClinicalTrials.gov Identifier:	NCT00213720
Health Authority:	France: Afssaps - French Health Products Safety Agency

Keywords provided by University Hospital, Strasbourg, France:

Hyperthyroidism
atrial fibrillation
quality of life
radioiodine treatment

Study placed in the following topic categories:

Heart Diseases
Quality of Life
Endocrine System Diseases
Endocrinopathy

Atrial Fibrillation
Thyroid Diseases
Hyperthyroidism
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 14, 2009