Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects - Full Text View

Sponsored by:	Lund University Hospital
Information provided by:	Lund University Hospital
ClinicalTrials.gov Identifier:	NCT00779298

Purpose

Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.

Condition
Healthy

Drug Information available for: Dextrose

U.S. FDA Resources

Study Type:	Observational
Official Title:	Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects

Further study details as provided by Lund University Hospital:

Groups/Cohorts
Healthy subjects Healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Detailed Description:

Ten healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus, were assessed by using a blinded crossover trial. The subjects were examined regarding blood glucose levels and GER after ingestion of 150g WWB or RWMB on two different occasions after an overnight fast. GER was measured using a standardized real time ultrasonography. GER was calculated as a percentage change in antral cross sectional area 15 and 90 minutes after the finished meal with WWB and RWMB. Finger-prick capillary samples were collected before and 40, 60, and 90 min after the start of the meal to measure blood glucose levels.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

All subjects were recruited from the population in a southern county of Sweden.

Criteria

Inclusion Criteria:

without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Exclusion Criteria:

with symptoms or prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00779298

Locations

Sweden, Skåne
Dept. of Medicine, Malmö University Hospital,
Malmö, Skåne, Sweden, 205 02

Sponsors and Collaborators

Lund University Hospital

More Information

Study ID Numbers:	Dnr 709/2004
Study First Received:	October 22, 2008
Last Updated:	October 23, 2008
ClinicalTrials.gov Identifier:	NCT00779298
Health Authority:	Sweden: Regional Ethical Review Board

Keywords provided by Lund University Hospital:

rye whole-meal bread
white-wheat bread
gastric emptying rate
postprandial glucose response
healthy subjects

Study placed in the following topic categories:

Healthy

ClinicalTrials.gov processed this record on January 14, 2009