Inclusion Criteria:

1. Histologically confirmed diagnosis of a CCR4-positive ATL and PTCL that is any of the following:

A. ATL (Adult T-Cell Leukemia-Lymphoma)

• Seropositive for anti-Human T-lymphotrophic Virus type-I (HTLV-I) antibody;
• Acute, Lymphoma, or Chronic phase with high-risk factors (within 14 days before the study entry);

B. PTCL (Peripheral T-Cell Lymphoma)

• Includes Mycosis Fungoides and Sezary Syndrome;

  2: Relapsed to the latest standard chemotherapy;

  3: Received at least one prior chemotherapy;

  4: After 4 weeks from a prior therapy;

  5: Have measurable disease;

  6:Eastern Cooperative Oncology Group (ECOG)　Performance Status score of 0 or 1;

  7: Male or female, at least 20 years and not older than 70 years of age;

  8: Signed written informed consent;

  9: Stay in hospital for 4 weeks;

  10: HBs antigen: negative, HBV-DNA: below the limit of quantification (within 14 days before the study entry);

  11: Adequate bone marrow, hepatic and cardiac function including the followings:

• Neutrophil count ≥ 1,500 /mm3,
• Platelets ≥ 75,000 /mm3,
• Hemoglobin ≥ 8.0 g/dL
• Serum creatinine ≤ 1.5 x ULN;
• Serum SGOT (AST) and SGPT (ALT) ≤ 2.5 x ULN (≤ 5.0 x ULN if considered due to disease involvement in liver);
• Serum bilirubin ≤ 1.5 x ULN (≤ 3.0 x ULN if considered due to disease involvement in liver)
• Serum calcium ≤ 11.0 mg/dL
• PaO2 ≥ 65 mmHg or SaO2 ≥ 90%
• No clinically significant Electrocardiogram abnormality
• Left Ventricular Ejection Fraction ≥ 50% [by ECHO or MUGA]

Exclusion Criteria:

1. Co-existing active infection or any co-existing medical condition that may compromise the safety of patients during the study, affect the patient's ability to complete the study, or interfere with interpretation of study results;
2. Active tuberculosis;
3. Prior stem cell transplantation;
4. Myocardial infarction (within 12 months prior to the study entry);
5. Concurrent acute or chronic hepatitis, or cirrhosis;
6. Anti-HCV: positive, Anti-HIV: positive
7. Concurrent active malignant disease;
8. Known allergic reaction to antibody therapy;
9. Concomitant treatment with systemic steroids;
10. Prior and Concurrent psychiatric disorder including dementia, epilepsy or any other CNS diseases;
11. Evidence of CNS metastasis at baseline;
12. Prior and Concurrent spinal cord disease;
13. Radiation therapy for bulky mass disease at the time of study entry or considered to require radiation therapy during the study;
14. Female patients who are pregnant or breast feeding;
15. Female patients of childbearing potential, unwilling to use an approved, effective means of contraception in accordance with the institution's standards;
16. Treatment with any other investigational agent within the 4 months prior to study entry;
17. For any reason is judged by the Investigator to be inappropriate for study participation, including an inability to communicate or cooperate with the Investigator.